Proteins: Energy, Heat and Signal Flow / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$144.27
Used and New from Other Sellers
Used and New from Other Sellers
from $126.66
Usually ships in 1-2 business days
(Save 18%)
Other sellers (Hardcover)
  • All (7) from $126.66   
  • New (5) from $126.66   
  • Used (2) from $180.87   

Overview

Computational modeling can provide a wealth of insight into how energy flow in proteins mediates protein function. Computational methods can also address fundamental questions related to molecular signaling and energy flow in proteins. Proteins: Energy, Heat and Signal Flow presents state-of-the-art computational strategies for studying energy redistribution, signaling, and heat transport in proteins and other molecular machines.

The first of four sections of the book address the transport of energy in molecular motors, which function through a combination of chemically driven large-scale conformational changes and charge transport. Focusing on vibrational energy flow in proteins and nanostructures, the next two sections discuss approaches based on molecular dynamics simulations and harmonic analysis. By exploring the flow of free energy in proteins, the last section examines the conformational changes involved in allosteric transitions and the role of coupled protein–solvent dynamics in conformational changes. It also presents computational approaches developed to locate pathways between protein structures.

The integrated presentation of this comprehensive, up-to-date volume emphasizes the interrelations between disparate computational approaches that have contributed to our understanding of energy flow in proteins and its role in protein function. By defining the forefront of research in this area, the book delineates the current challenges and opportunities in developing novel methods and applications for the evolving study of energy flow in molecular machines and nanomaterials.

Read More Show Less

Editorial Reviews

From the Publisher
… a useful guide for practitioners of molecular dynamics, theorists interested in structural biology, and users of modeling software seeking to understand the methods in more depth. The book is well organized, produced, and edited. References are up-to-date and comprehensive.
—Harry A. Stern, University of Rochester, in the Journal of the American Chemical Society
Read More Show Less

Product Details

  • ISBN-13: 9781420087031
  • Publisher: CRC Press
  • Publication date: 9/28/2009
  • Edition number: 1
  • Pages: 415
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

David M. Leitner is a Professor of Chemistry at the University of Nevada in Reno.

John E. Straub is a Professor of Chemistry at Boston University in Boston, Massachusetts.

Read More Show Less

Table of Contents

ENERGY TRANSDUCTION IN MOLECULAR MOTORS

Energy Balance and Dynamics of Kinesin Motors, Changbong Hyeon and José N. Onuchic

Mechanochemical Coupling in Molecular Motors: Insights from Molecular Simulations of the Myosin Motor Domain, Haibo Yu, Yang Yang, Liang Ma, and Qiang Cui

The Chemomechanical Coupling Mechanisms of Kinesin and Dynein, Yi Qin Gao and Qiang Shao

Electron Transfer Reactions Coupled with Proton Translocation: Cytochrome Oxidase, Proton Pumps, and Biological Energy Transduction, Alexei Stuchebrukhov

VIBRATIONAL ENERGY FLOW IN PROTEINS: MOLECULAR DYNAMICS-BASED METHODS

Molecular Dynamics Simulation of Proteins: Two Models of Anharmonic Dynamics, Akinori Kidera, Kei Moritsugu, Yasuhiro Matsunaga, and Hiroshi Fujisaki

Energy Flow Pathways in Photoreceptor Proteins, Takahisa Yamato

Nonequilibrium Molecular Dynamics Simulation of Photoinduced Energy Flow in Peptides: Theory Meets Experiment, Phuong H. Nguyen, Peter Hamm, and Gerhard Stock

Energy Flow Analysis in Proteins via Ensemble Molecular Dynamics Simulations: Time-Resolved Vibrational Analysis and Surficial Kirkwood–Buff Theory, Masataka Nagaoka, Isseki Yu, and Masayoshi Takayanagi

VIBRATIONAL ENERGY FLOW IN PROTEINS AND NANOSTRUCTURES: NORMAL MODE-BASED METHODS

Directed Energy Funneling in Proteins: From Structure to Function, Yong Zhang and John E. Straub

A Minimalist Network Model for Studying Biomolecular Vibration, Mingyang Lu and Jianpeng Ma

Heat Transport in Proteins, David M. Leitner

Heat Transfer in Nanostructures, Dvira Segal

CONFORMATIONAL TRANSITIONS AND REACTION PATH SEARCHES IN PROTEINS

Tubes, Funnels, and Milestones, Ron Elber, Krzysztof Kuczera, and Gouri S. Jas

Pathways and Rates for Structural Transformations of Peptides and Proteins, David J. Wales, Joanne M. Carr, Mey Khalili, Vanessa K. de Souza, Birgit Strodel, and Chris S. Whittleston

Energy Flow and Allostery in an Ensemble, Vincent J. Hilser and Steven T. Whitten

Molecular Dynamics Simulation Studies of Coupled Protein and Water Dynamics, Douglas J. Tobias, Neelanjana Sengupta, and Mounir Tarek

Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)