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Doody's Review ServiceReviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This is Part B of a two-volume set on proteolytic enzymes in coagulation, fibrinolysis, and complement activation. Part B is a collection of reviews of methods for complement activation and fibrinolysis and the esoteric area of pharmacological interest in nonmammalian blood coagulation factors and inhibitors. The contributors are experts in their respective areas.
Purpose: The purpose is to update the knowledge base in complement activation and fibrinolysis and nonmammalian blood coagulation factors and inhibitors. This is a worthwhile objective because this area is expanding rapidly. The emphasis on nonmammalian factors and inhibitors is especially important because of the pharmacological application and clinical interest in fibrinolytic agents and coagulation inhibitors.
Audience: The intended audience is biochemists, molecular biologists, pharmacologists, and hematologists with an interest in blood coagulation, fibrinolysis, and complement activation. This book should be of special interest to anyone with an interest in structure-function properties of these proteins, the application of recombinant methods to study of these proteins, the pharmacological use of some of these proteins as fibrinolytic agents, and the mechanisms of action.
Features: The features of this attractive book are those shared by any Methods in Enzymology monograph. The book is written in the standard Methods format with easy-to-read text, attractive paragraph formatting, and inclusion of clear and useful figures. The number of illustrations and quality is suitable. The references are up-to-date and will be useful for anyone needing to refer to the most current or the original methods description. The table of contents is well structured and sufficiently detailed.
Assessment: This book contains appropriately detailed methods descriptions that are written concisely and use numerous figures to guide the reader through the methods. This book will be very useful for researchers in the area who need to have ready access to descriptions of methods of relevance to their work. This book should be individually purchased by researchers in this area and included in the medical library.