Proteome Research: Mass Spectrometry / Edition 1

Proteome Research: Mass Spectrometry / Edition 1

by Peter James
     
 

ISBN-10: 3540672567

ISBN-13: 9783540672562

Pub. Date: 12/12/2000

Publisher: Springer Berlin Heidelberg

Recent advances in large scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Mass spectrometry is the method of choice for the rapid large-scale identification of these proteomes

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Overview

Recent advances in large scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Mass spectrometry is the method of choice for the rapid large-scale identification of these proteomes and their modifications. This is the first book to extensively cover the applications of mass spectrometry to proteome research.

Product Details

ISBN-13:
9783540672562
Publisher:
Springer Berlin Heidelberg
Publication date:
12/12/2000
Series:
Principles and Practice Series
Edition description:
Softcover reprint of the original 1st ed. 2001
Pages:
274
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

1Mass Spectrometry and the Proteome
2Basics of Triple-Stage Quadrupole/Ion-Trap Mass Spectrometry: Precursor, Product and Neutral-Loss Scanning. Electrospray Ionisation and Nanospray Ionisation
3The Basics of Matrix-Assisted Laser Desorption, Ionisation Time-of-Flight Mass Spectrometry and Post-Source Decay Analysis
4Data-Controlled Micro-Scale Liquid Chromatography - Tandem Mass Spectrometry of Peptides and Proteins: Strategies for Improved Sensitivity, Efficiency and Effectiveness
5Solid-Phase Extraction - Capillary Zone Electrophoresis-Mass Spectrometry Analysis of Low-Abundance Proteins
6Protein Identification by Peptide-Mass Fingerprinting
7Protein Identification by SEQUEST
8Interpreting Peptide Tandem Mass-Spectrometry Fragmentation Spectra
9Automated Interpretation of Peptide Tandem Mass Spectra and Homology Searching
10Specific Detection and Analysis of Phosphorylated Peptides by Mass Spectrometry
11Glycoproteomics: High-Throughput Sequencing of Oligosaccharide Modifications to Proteins
12Proteomics Databases
13Quo Vadis
Subject Index

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