Proteomics for Biological Discovery / Edition 1

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Tools and guidance from a team of experts to meet the challenges of the post-genomics era

Proteomics for Biological Discovery presents the state of the art in the field of proteomics and offers readers new tools and techniques to advance their own research. Moreover, the publication provides readers with an understanding of new and emerging directions for proteomics research and applications.

The publication begins with an introduction that examines the rise of proteomics and discusses potential benefits, such as new diagnostics and therapeutics, that further proteome-level research promises. Next, the publication is divided into three sections:

  • Foundations of Proteomics
  • Functional Proteomics
  • Novel Approaches in Proteomics

All the tools of proteomics, from conventional to novel techniques, are examined, including:

  • Proteomic analysis using 2D-PAGE
  • Gel-free proteomics to measure protein abundances
  • Characterization of intact noncovalent protein complexes
  • Three-dimensional protein structure determination
  • Protein localization by imaging techniques
  • Protein arrays

The publication also covers key foundations of proteomics: separations, bioinformatics, and automation. Each chapter, written by an expert, addresses technological limitations, emerging approaches, and key questions requiring further investigation. In addition, each chapter explores future applications for industry and basic science.

This reference brings readers in touch with a team of experts who are leading the proteomics revolution. It is, therefore, recommended for students and researchers across the gamut of fields in biomedical research, including biochemistry, protein chemistry, molecular genetics, cell and developmental biology, and bioinformatics.

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Editorial Reviews

From the Publisher

"The authors know what they are talking about and any chapter would make a pretty good stand alone review." (Genetical Research, 2007)

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Product Details

  • ISBN-13: 9780471160052
  • Publisher: Wiley
  • Publication date: 6/23/2006
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 360
  • Product dimensions: 6.79 (w) x 10.12 (h) x 0.66 (d)

Table of Contents

1 Mass spectrometry : the foundation of proteomics 1
2 Proteomic analysis by two-dimensional polyacrylamide gel electrophoresis 19
3 Isotope labeling in quantitative proteomics 47
4 Mass spectrometric characterization of post-translational modifications 63
5 Technologies for large-scale proteomic tandem mass spectrometry 91
6 Protein fractionation methods for proteomics 111
7 Protein localization by cell imaging 137
8 Characterization of functional protein complexes 157
9 Structural proteomics by NMR 171
10 Protein microarrays 189
11 Microfluidies-based proteome analysis 205
12 Single cell proteomics 225
13 Diagnostic proteomics 247
14 Automation in proteomics 277
15 Bioinformatics tools for proteomics 289
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