As more patients seek information about family risks of psychiatric illness -- an interest likely to increase as gene-identification studies are publicized -- most psychiatrists agree it is their role to discuss these issues but admit they are ill-prepared to do so. Psychiatric Genetics addresses that need as the first book to focus on clinical applications of genetics in psychiatry. It covers issues involved in genetic counseling, the interpretation of familial and genetic information for clinical use, ...

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Psychiatric Genetics: Applications in Clinical Practice

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As more patients seek information about family risks of psychiatric illness -- an interest likely to increase as gene-identification studies are publicized -- most psychiatrists agree it is their role to discuss these issues but admit they are ill-prepared to do so. Psychiatric Genetics addresses that need as the first book to focus on clinical applications of genetics in psychiatry. It covers issues involved in genetic counseling, the interpretation of familial and genetic information for clinical use, information regarding risks associated with specific psychiatric disorders, risk/benefit considerations related to medication use during pregnancy, and the ethical and social implications of psychiatric genetic knowledge and research -- including the prospects for genetic testing.

While other books have been written for the genetics community, this volume is addressed to practitioners: a clinically relevant resource that can help them understand the often bewildering flood of information about genetics -- information difficult to interpret, let alone integrate into practice -- and enable them to respond to patients' requests to predict the risk of recurrence of psychiatric illness or provide information about reproductive and pregnancy-related issues. Experts from psychiatry, genetic epidemiology, molecular genetics, genetic counseling, cognitive psychology, and ethics focus on issues that have received little attention elsewhere yet are of increasing importance to clinicians. Written at a level that assumes no particular expertise in genetics, the book features these immediately applicable benefits: • It offers a framework for understanding and critically evaluating the psychiatric genetic research literature, enabling clinicians to better understand the meaning and limitations of genetic discoveries when patients raise questions about media reports. • It provides a resource for clinicians who would like more information about the role and content of genetic counseling, outlining a typical counseling session while demonstrating how risks are estimated and discussed.• It summarizes genetic aspects of major psychiatric conditions -- from childhood-onset disorders through psychotic, mood, and anxiety disorders to dementia -- as well as neuropsychiatric manifestations of other genetic disorders.• It alerts clinicians to risk/benefit considerations related to medication use during pregnancy.• It covers the ethical, legal, and social implications of genetic research and counseling, illustrating the dilemmas that arise with new advances. Whether used as a clinical guide, reference, or ancillary text, this book sets the standard for the application of psychiatric genetic knowledge in everyday practice. Psychiatrists, mental health clinicians, and genetic counselors will find it an essential resource for all patient encounters in which genetic issues arise.

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Editorial Reviews


It serves both as a clinical reference and teaching text, and professionals in multiple disciplines would find it an excellent source for training. The format, structure, llustrations, and chapter order all contribute to a clean, orderly progression of knowledge. The selected authors all demonstrate significant expertise in their fields, and the editors have produced a valuable work that introduces a substantial amount of information in a relatively brief space.

The Journal of Neuropsychiatryand Clinical Neurosciences

This book succeeds admirably, distilling a vast amount of information into an easily readable volume emphasizing practical implications of genetics.

Doody's Review Service
Reviewer: Raj Tummala, MD (Wyeth Pharmaceuticals)
Description: This is a comprehensive and focused review of the clinical and practical applications of genetics in psychiatric disorders.
Purpose: The purpose is to provide an interpretive review of the growing field of genetics and its practical applications for clinicians treating various psychiatric disorders.
Audience: The audience includes anyone dealing with psychiatric patients including students, clinicians, researchers, etc.
Features: Genetics as a field of research has been exploding over the last decade, giving us some insight into the pathophysiology of psychiatric disorders. In this book, the authors provide a nice overview of the recent advances in psychiatric genetics and their application to clinical practice. A primer on genetics with a discussion of methods, genetic linkage, and association analyses leads into the principles of genetic counseling. Each section is in the format of a question with a detailed answer. Evidence is from genetic studies that are listed as well as from simple to understand case vignettes. Risk communication is presented in verbal, numerical, and visual formats. The genetics of specific psychiatric disorders covers childhood onset disorders, psychotic disorders, mood and anxiety disorders, and Alzheimer's disease. Each disease state is discussed in detail with clinical phenotypes, genetic epidemiology with family, twin, and adoption studies. Of special note are the chapters on the neuropsychiatric aspects of various genetic disorders and perinatal psychiatry and teratogenicity. The ethical, legal, and social implications such as genetic testing/profiling are nicely covered. Each chapter has a detailed reference section. Information is highlighted in the form of tables, graphs, and pictures to add clarity.
Assessment: This is a very well written, focused review covering the major aspects of genetics as they apply to psychiatric disorders. The book is easy to read with a clinical and practical twist.
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Product Details

  • ISBN-13: 9781585628797
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 2/20/2009
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 337
  • Product dimensions: 0.60 (w) x 0.90 (h) x 0.07 (d)
  • File size: 5 MB

Meet the Author

Jordan W. Smoller, M.D., Sc.D., is Associate Professor of Psychiatry at Harvard Medical School; Associate Professor in the Department of Epidemiology at the Harvard School of Public Health; Assistant Vice Chair of the Department of Psychiatry at Massachusetts General Hospital; Director of the Psychiatric Genetics Program in Mood and Anxiety Disorders in the Department of Psychiatry; co-Director of the Genetics and Genomics Unit of the Massachusetts General Hospital Clinical Research Program; and a faculty member in the Center for Human Genetic Research at Massachusetts General Hospital in Boston, Massachusetts.

Beth Rosen Sheidley, M.S., CGC, is Associate Professor of the Practice and Co-Director of Research and Professional Development in the Genetic Counseling Program in the Department of Biology at Brandeis University in Waltham, Massachusetts; and Genetic Counselor in the Division of Genetics and Metabolism at Tufts Medical Center, Floating Hospital for Children, in Boston, Massachusetts.

Ming T. Tsuang, M.D., Ph.D., D.Sc., is Behavioral Genomics Endowed Chair and University Professor at the University of California; Distinguished Professor of Psychiatry and Director of the Center for Behavioral Genomics in the Department of Psychiatry at the University of California, San Diego in La Jolla, California; Adjunct Professor and Director of the Harvard Institute of Psychiatric Epidemiology and Genetics in the Department of Epidemiology at the Harvard School of Public Health in Boston, Massachusetts; and Senior Lecturer at the Massachusetts Mental Health Center Academic Division of Public Psychiatry in the Department of Psychiatry at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, Massachusetts

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Table of Contents

Preface. Part 1: General Principles. Psychiatric genetics: a primer. Principles of genetic counseling. Risk communication: simple tools to foster understanding. Part 2: Genetics of Specific Disorders. Genetics of childhood-onset psychiatric disorders. Genetics of schizophrenia and psychotic disorders. Genetics of mood and anxiety disorders. Genetics of Alzheimer's disease. Neuropsychiatric aspects of genetic disorders. Part 3: Special Topics. Perinatal psychiatry and teratogenicity. Ethical, legal, and social implications of psychiatric genetics and genetic counseling. The road ahead. Glossary. Index.

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