Psychiatric Genetics: Methods and Reviews

by Marion Leboyer (Editor), Frank Bellivier (Editor)

Overview

Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endophenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed. This book will serve as an essential handbook for psychiatrists, psychologists, and geneticists involved in the genetics of psychiatric disorders.

Product Details

ISBN-13:	9781588290373
Publisher:	Springer-Verlag New York, LLC
Publication date:	09/10/2002
Series:	Methods in Molecular Medicine , #77
Edition description:	2003
Pages:	268
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Psychiatric Genetics.- Methods in Psychiatric Genetics: Advantages and Limits.- Analytical Methods Applied to Psychiatric Genetics.- Genetic Markers in Psychiatric Genetics.- Clinical Assessment in Psychiatric Genetics.- Genetic Association Studies.- New Phenotypic Approaches.- Searching for Alternative Phenotypes in Psychiatric Genetics.- Intermediate Cognitive Phenotypes Associated with Schizophrenia.- Biochemical Endophenotypes in Personality Disorders.- Electrophysiological Phenotypes.- Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia.- Conclusion.- Psychiatric Genetics.

Editorial Reviews

Psychologists and psychiatrists from France, the US, and Germany survey the tools and methods that are currently available to analyze the genetic basis of behavioral phenotypes, and offer archetypical examples obtained using them. They consider study design, molecular techniques, clinical interviews, and population sampling methods. They also look at alternative methods for characterizing phenotypes in order to identify entities with better genetic validity. Among specific topics are genetic markers, clinical assessment, genetic association studies, intermediate cognitive phenotypes associated with schizophrenia, and electrophysiological phenotypes. Annotation c. Book News, Inc., Portland, OR

"...a valiant attempt to make sense of a substantial portion of the methodological aspects of research in psychiatric genetics. Students and senior investigators should both give serious consideration to this book's arguments and advice." - Genes, Brain and Behavior

"...provides a relatively succinct introduction to a range of issues relating to the filed of psychiatric genetics...would be an excellent book for a young researcher about to enter the field of psychiatric genetics and would enable him or her to obtain a rapid overview of methodological issues." - Journal of Medical Genetics

"...great for getting new ideas as well as suggestions for how to deal with practical research questions." - Psychological Medicine

"This book is very useful for students or psychiatrists interested in genetics and how it applies to psychiatric illness. It is one of few in the field to give a comprehensive review of the field." -Doody's Health Sciences Book Review Journal

"Marion Leboyer and Frank Bellivier have put together a very good review of the variety of methods and approaches previously used in this complex area of research and, for this reason, this book provides a useful text for someone entering the field of psychiatric genetics." -Human Genetics

From the Publisher