Psychiatric Genetics: Methods and Reviews / Edition 1

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Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endophenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed. This book will serve as an essential handbook for psychiatrists, psychologists, and geneticists involved in the genetics of psychiatric disorders.

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Editorial Reviews

Doody's Review Service
Reviewer: Stephanie R. Exum, MD (Rush University Medical Center)
Description: This book, part of the Methods in Molecular Medicine series, is a complete review of the field of psychiatric genetics.
Purpose: The purpose is to provide a comprehensive overview of the tools and methods that are currently available in psychiatric genetics. This is an important and timely topic as more research is being performed in this area. The book meets the authors' objectives and more.
Audience: This book is written for graduate level students and/or psychiatrists interested in psychiatric genetics and who also have a basic level of knowledge in the field of genetics. Most of the authors and contributors are affiliated with teaching and/or research institutions.
Features: The field of psychiatric genetics is covered from nearly every aspect. The book reviews methods involved with the research tools that are available as well as problems and ethical dilemmas that may arise. The book gives very detailed information on analytical methods and study designs. The author assumes that readers have a solid foundation in the field of genetics and begins the discussion of research from an advanced level.
Assessment: This book is very useful for students or psychiatrists interested in genetics and how it applies to psychiatric illness. It would be more useful to one interested in research in psychiatric genetics than it would be to the general practitioner. It is one of few in the field to give a comprehensive review of the field.
From The Critics
Psychologists and psychiatrists from France, the US, and Germany survey the tools and methods that are currently available to analyze the genetic basis of behavioral phenotypes, and offer archetypical examples obtained using them. They consider study design, molecular techniques, clinical interviews, and population sampling methods. They also look at alternative methods for characterizing phenotypes in order to identify entities with better genetic validity. Among specific topics are genetic markers, clinical assessment, genetic association studies, intermediate cognitive phenotypes associated with schizophrenia, and electrophysiological phenotypes. Annotation c. Book News, Inc., Portland, OR

3 Stars from Doody
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Product Details

  • ISBN-13: 9781588290373
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/10/2002
  • Series: Methods in Molecular Medicine Series, #77
  • Edition description: 2003
  • Edition number: 1
  • Pages: 268
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.69 (d)

Table of Contents

Part I. Introduction

Psychiatric Genetics: Overview on Achievements, Problems, Perspectives
Wolfgang Maier

Part II. Methods in Psychiatric Genetics: Advantages and Limits

Analytical Methods Applied to Psychiatric Genetics
Elena L. Grigorenko and David L. Pauls

Genetic Markers in Psychiatric Genetics
Thomas Bourgeron and Bruno Giros

Clinical Assessment in Psychiatric Genetics
Philip Gorwood

Genetic Association Studies: Definition of Cases and Controls
Frank Bellivier

Part III. New Phenotypic Approaches

Searching for Alternative Phenotypes in Psychiatric Genetics
Marion Leboyer

Intermediate Cognitive Phenotypes Associated with Schizophrenia
Michael F. Egan and Terry E. Goldberg

Biochemical Endophenotypes in Personality Disorders
Antonia S. New and Larry J. Siever

Electrophysiological Phenotypes
Robert Freedman

Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia
Joseph H. Callicott and Daniel R. Weinberger

Part IV. Conclusion

Psychiatric Genetics: Future and Prospects
Ming T. Tsuang, Levi Taylor, and Stephen V. Faraone


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