Psychiatric Neuroimaging Research: Contemporary Strategies

Psychiatric Neuroimaging Research: Contemporary Strategies

by Darin D. Dougherty
     
 

ISBN-10: 0880488441

ISBN-13: 9780880488440

Pub. Date: 05/28/2001

Publisher: American Psychiatric Publishing, Incorporated

The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools.

This volume brings you up to date on the latest developments by providing insight into the methodology of

Overview

The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools.

This volume brings you up to date on the latest developments by providing insight into the methodology of experimental design of the numerous neuroimaging articles being published in today's peer-reviewed journals. Revealing the remarkable wealth of neuroimaging's potential contributions to psychiatry, 49 distinguished contributors use accounts of their own research to illustrate the power of particular paradigmatic techniques. These techniques hold promise not only for delineating pathophysiology and advancing neuroscience, but also for yielding discoveries of direct clinical significance, such as diagnostic testing, predictors of treatment response, and new medications.

Focused specifically on applications in psychiatry, these chapters are uniquely organized around experimental paradigms rather than psychiatric disorders: • Using magnetic resonance imaging (MRI) to detect and characterize subtle, easily overlooked abnormalities in schizophrenia and schizotypal personality disorder.• Testing specific hypotheses regarding the functional integrity of implicated neural systems within the brain as part of cognitive activation studies of schizophrenia and obsessive-compulsive disorder (OCD).• Assessing the roles of the amygdala and striatum in anxiety disorders, including masked stimuli and other task manipulation methods to assay nonconscious brain activity. • Investigating the neural correlates of psychiatric symptoms in anxiety disorders, using script-driven imagery and in vivo exposure to experimentally manipulate study conditions.• Capturing the often elusive symptoms of hallucinations and psychomotor tics using innovative imaging techniques.• Using transcranial magnetic stimulation (TMS) to investigate how the brain regulates mood.

Other fascinating topics include using positron emission tomography (PET) and single photon emission computed tomography (SPECT) to discern the therapeutic mechanisms of psychotropic medications and enhance the development of new medications; integrating structural and functional imaging to treat major depression; using magnetic resonance spectroscopy (MRS) to quantify brain concentrations of exogenous compounds; using MRI to visualize circuits implicated in developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and anxiety, including ground-breaking studies of children; using functional MRI in animals and its applications in psychiatric research; and exploring the use of neuroimaging methods to investigate genetic contributions to normal cognitive function.

Specialists and general clinicians alike will find much of interest in this definitive look at the exciting developments in neuroimaging today and how they can enhance our understanding and treatment of psychiatric disorders. This comprehensive text with its extensive illustrations and annotations will also prove a welcome addition to any course in the neurosciences.

American Psychiatric Publishing

Product Details

ISBN-13:
9780880488440
Publisher:
American Psychiatric Publishing, Incorporated
Publication date:
05/28/2001
Edition description:
1ST
Pages:
448
Product dimensions:
6.00(w) x 9.00(h) x 1.15(d)
Age Range:
18 Years

Table of Contents

Introduction. Morphometric magnetic resonance imaging studies: findings in schizophrenia. Mapping cognitive functioning in psychiatric disorders. Using neuroimaging to study implicit information processing. Symptom provocation studies: the example of anxiety disorders. Symptom capture: a strategy for pathophysiologic investigation in functional neuropsychiatric imaging. New methods for understanding how the brain regulates mood: serial perfusion functional magnetic resonance imaging and transcranial magnetic stimulation. Neuroimaging studies of treatment response: the example of major depression. In vivo neuroreceptor imaging techniques in psychiatric drug development. "Functional" neuroreceptor imaging: the example of studies of synaptic dopamine activity with single photon emission tomorgraphy. In vivo neuroreceptor characterization: the example of [11C] flumazenil positron emission tomography in the investigation of anxiety disorders. Integration of structural and functional imaging: examples in depression research. Magnetic resonance spectroscopy in psychiatric illness. Using magnetic resonance imaging to visualize circuits implicated in developmental disorders: the examples of attention-deficit/hyperactivity disorder. Functional magnetic resonance imaging in animals: applications in psychiatric research. Toward a neurocognitive genetics: goals and issues. Index.

American Psychiatric Publishing

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