Psychoneuroendocrinology: The Scientific Basis of Clinical Practice [NOOK Book]


The mind-body connection is one of the hottest topics in medicine today, documented by enormous amounts of data regarding hormone effects on the brain and behavior.

Yet it is only now -- with the debut of this thought-provoking volume -- that we find an up-to-date, sophisticated reference that focuses on the clinical relevance of behavioral endocrinology and is written for practicing clinicians and researchers.

This wide-ranging volume shows ...

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Psychoneuroendocrinology: The Scientific Basis of Clinical Practice

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The mind-body connection is one of the hottest topics in medicine today, documented by enormous amounts of data regarding hormone effects on the brain and behavior.

Yet it is only now -- with the debut of this thought-provoking volume -- that we find an up-to-date, sophisticated reference that focuses on the clinical relevance of behavioral endocrinology and is written for practicing clinicians and researchers.

This wide-ranging volume shows how the principles and emerging findings of psychoneuroendocrinology can inform modern clinical practice and lead to new breakthroughs in future science and practice. Here, leading authorities -- internationally respected researchers and practicing clinicians -- review empirical findings in their areas of expertise, highlight the clinical significance of these findings, and provide, wherever appropriate, clinical guidelines for the management of patients.

Beginning with a lively history of psychoneuroendocrinology (including its many false starts), this book continues on to discussions of the hypothalamic-pituitary-adrenal axis hormone system, the gonadal hormone system, and the thyroid hormone system from each of the three paths generally used for psychoneuroendocrinological investigation: • Alterations in endogenous hormone levels observed in primary psychiatric illness• Psychiatric concomitants or sequelae of hormonal dysregulation in primary endocrinologic illness• Behavioral effects of exogenously administered hormones or hormone antagonists (both the study of the side effects of hormonal medications and the use of hormones and hormone antagonists as psychotropic medications)

An unmatched diversity of topics reveals the full breadth and depth of this volume: diabetes mellitus, corticosteroid effects on mood and cognition, Cushing's syndrome and Addison's disease, oral contraceptives and estrogen replacement therapy, psychiatric illness associated with the menstrual cycle and perimenopause, postpartum behavioral changes, anabolic/androgenic steroid use, and a thorough review of thyroid function in psychiatric disorders.

Particularly fascinating are sections on the role of neuropeptides and hypothalamic-releasing factors in psychiatric illness, the use of laboratory tests and imaging procedures in evaluating hormonal function in psychiatric patients, the place of newer "alternative" hormonal medications such as melatonin and DHEA in therapeutics, and a provocative and compelling final chapter on the role stress plays in precipitating illness.

Designed for both clinician and researcher-scientist, this richly informative guide will also prove an invaluable addition to graduate courses in neuroscience, neuroendocrinology, the biological basis of behavior, and consultation psychiatry. Neuroscientists/neurologists, endocrinologists, obstetricians/gynecologists, internists, family practitioners, nurses, and interested laypersons round out the wide audience for this remarkable volume.

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Editorial Reviews

Psychiatric Times
In an era when our profession must prove uniqueness of our skill set, as distinct from psychologists' skills, every psychiatrist should be versed in the topics covered in the book.... The chapters presented here review and then summarize clinically relevant pearls so that the practicing psychiatrist can give the best current knowledge to patients and non-psychiatric colleagues. This volume is most highly recommended with the psychiatrist primarily in mind. Nurse practitioners, researchers, psychologists, residents and medical students would also benefit. Most will probably refer to it frequently as our practice demands consistent, highest competency in the relationships between endocrine function and behavioral disturbances.
As a whole, this book is certainly the first comprehensive integrated approach of modern psychoneuroendocrinology. It is a must for not only graduates but also basic and clinical researchers who need to understand better their own specific field of interest and are willing to play a more active role in holistic perspectives of human functioning and dysfunctioning.
Bulletin of the Menninger Clinic
This authoritative volume, compiled and written by the leading lights in these fields, will serve as a highly useful source for those new to the area and as a superb review for those needing a refresher or update. Each of the 19 clearly written and highly referenced chapters provides historical context for the topic under consideration, offers sufficient basic biological underpinning and description to clearly explain the subjects at hand and to show how they fit into the larger schemes of biological psychiatry, and presents clinical and treatment implications of the discussions.... Readers will be able to turn to this volume for individual chapters or, alternatively, easily use the text for a graduate, post-graduate, or residency level seminar.
This fine textbook, edited by two eminent experts in the field with contributions from many others of equal stature, is a readable, practical, and well-researched volume that begins with a fascinating history of psychoneuroendocrinology and guides the reader through the various components of the endocrine system as they relate to psychopathology.
Doody's Review Service
Reviewer: Corey Goldstein, MD (Rush University Medical Center)
Description: This is an excellent overview of the interface between psychiatry and endocrinology and is packed with information that is not only helpful to the researcher, but also to the average clinician.
Purpose: According to the authors, the purpose is to show how principles and emerging findings in psychoneuroendocrinology can inform modern clinical practice and lead to new breakthroughs in future practice. These are worthy objectives, without question. The book does a fine job of meeting the objectives in an easy-to-read format that is directly applicable to the clinician.
Audience: The book is written for clinicians as well as researcher-scientists. The introduction to the book further breaks these categories down to psychiatrists, neurologists, endocrinologists, obstetrician/gynecologists, primary care physicians, psychologists, nurses, and advanced students. I would agree that this book has a very wide audience because of its overlap of many disciplines. The authors are highly credible and leading authorities within their disciplines.
Features: The book covers the various hormonal categories and their interplay with psychiatric symptomatology, laboratory testing, and imaging. The last part of the book discusses the role of stress and neuroendocrine function. The book is particularly good at getting its points across in a practical format and it can be used as a textbook or as a reference. One of the book's strengths is part IV, which covers thyroid hormones in nice detail without the dryness that could be associated with a book of this nature. Certain parts of the book should be essential reading for the average psychiatrist in practice.
Assessment: I have not seen a book on this topic that is so relevant, easy to read, and clinically useful on a daily basis. It is packed with information on the important interplay between psychiatry and endocrinology, with a good amount of neurology. This book will be a valuable resource in my clinical and research practice.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781585627578
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 8/13/2008
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 606
  • Product dimensions: 0.60 (w) x 0.90 (h) x 0.11 (d)
  • File size: 5 MB

Meet the Author

Owen M. Wolkowitz, M.D., is Professor of Psychiatry and Director of the Psychopharmacology Assessment Clinic at the University of California, San Francisco, Medical Center. He was awarded the Curt P. Richter Prize in 1992 by the International Society of Psychoneuroendocrinology for his contributions to the field.

Anthony J. Rothschild, M.D., is the Irving S. and Betty Brudnick Professor and Director of Clinical Research, Department of Psychiatry, University of Massachusetts Medical School, and its clinical partner, UMass Memorial Medical Center, in Worchester, Massachusetts.

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Table of Contents

Part I: Introduction. Introduction and overview. Historical roots of psychoneuroendocrinology. Part II: Peptide Hormones. Neuropeptides and hypothalamic releasing factors in psychiatric illness. Chronobiology and melatonin. Prolactin, growth hormone, insulin, glucagon, and parathyroid hormone: psychobiologic and clinical implications. Part III: Adrenocortical Hormones. The hypothalamic-pituitary-adrenal axis and psychiatric illness. Psychiatric manifestations of hyper- and hypoadrenocorticism (Cushing's and Addison's diseases). Psychiatric effects of glucocorticoid hormone medications. Dehydroepiandrosterone (DHEA) in psychoneuroendocrinology. Part IV: Gonadal Hormones. Menstrual cycle and perimenopause-related affective disorders. Endogenous gonadal hormones in postpartum psychiatric disorders. Clinical psychotropic effects of gonadal hormone medications in women. Psychiatric effects of exogenous anabolic/androgenic steroids. Part V: Thyroid Hormones. Thyroid function in psychiatric disorders. Psychiatric and behavioral manifestations of hyper- and hypothyroidism. Thyroid hormone treatment of psychiatric disorders. Part VI: Laboratory Testing in Psychoneuroendocrinology. Laboratory evaluation of neuroendocrine systems. Endocrine imaging in depression. Part VII: Stress. Stress and neuroendocrine function: individual differences and mechanisms leading to disease. Index.

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