Psychoneuroimmunology, Two-Volume Set [NOOK Book]


Psychoneuroimmunology is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active ...
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Psychoneuroimmunology, Two-Volume Set

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Psychoneuroimmunology is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active areas of research that have not previously been reviewed. As illustrated in this fourth edition, interdisciplinary research continues to provide evidence that the brain and immune system represent a single, integrated system of defense.

* Fully revised and updated fourth edition of the classic reference
* Provides a neuroendocrine and immunologic perspective for the behavioral scientist
* Provides a behavioral and neuroscience perspective for the immunologist
* Helps the reader translate basic science findings into clinically relevant information
* Provides the reader with the background for and foundation of integrative research and integrative medicine
* Provides an encyclopedic resource for advanced undergraduates and for pre- and post-doctoral students as well as active researchers

Audience: *Psychologists studying behavior-neuroendocrine-immune interactions *Neuroscientists studying brain-immune system interactions *Endocrinologists studying neuroendocrine-immune interactions *Immunologists studying neuroendocrine-immune interactions *Immunologists studying immunoregulatory processes *Psychiatrists and psychologists researching the experimental foundations of psychosomatic relationships *Physicians and biomedical scientists studying brain-behavior-immune system interactions in the pathogenesis of disease *Pre- and postdoctoral students in psychology, the neurosciences (e.g., neuroendocrinology, neurochemistry, neuroanatomy), microbiology and immunology, endocrinology, physiology, and pharmacology.

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Editorial Reviews

The field addresses the relationships between the brain and the immune system and their implications for health and disease, and it has grown substantially since the 1981 publication of the first edition of this reference (with 17 papers) and the second edition ten years later. Here this many-faceted subject is addressed in 67 contributions contained in two volumes; much, of course, is new. After a foreword discussing cytokines as mediators of central and peripheral immune- neuroendocrine interactions, coverage encompasses a wide range of topics connected with immunity, among them: age-related phenomena, marijuana, melatonin, biological rhythms, the blood-brain barrier, diseases of the adult central nervous system, sleep, fever, hypnosis, conditioning, stress, social interactions, schizophrenia, depression, multiple sclerosis, psoriasis, the menstrual cycle, HIV infection, wound healing, periodontal disease, alcoholism, and the list goes on. Editor Ader is affiliated with the U. of Rochester Medical Center, as is co-editor Nicholas Cohen; the third editor, David L. Felten and is with the Loma Linda University School of Medicine. Contributors are from everywhere. Annotation c. Book News, Inc., Portland, OR (
Doody's Review Service
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This two-volume work attempts to integrate a number of biological processes to show how the behavioral, neural, and endocrine systems influence immunologically-based diseases and in turn, how immune processes affect diseases believed to be primarily of behavioral, endocrine, or neurologic origin. The previous edition was published in 2001.
Purpose: It is hoped that the book will promote interdisciplinary research in the laboratory and in the clinic and, as such, it is addressed to a broad audience. As noted in the preface, this theme of interdisciplinary integration is now endorsed by the National Institutes of Health (NIH) and thus the approach taken in the development of this book reflects the current paradigm in research and clinical activities. The fields that are represented change so rapidly that it is clear that the time had come for a new edition.
Audience: The audience includes laboratory and clinical investigators in endocrinology, immunology, neurochemistry, neurophysiology, pharmacology, psychiatry, psychology, virology, and medical specialists in such areas as allergic and infectious diseases, neurology, oncology, and rheumatology. There are probably other investigators who will find these volumes useful as well. The editor, section editors, and authors are all experts in their specific areas.
Features: The book is divided into five sections, each with a specific theme. These divisions and the chapter titles are somewhat different from the third edition, although there are authors who have chapters in both editions. In general, the titles of most chapters suggest that they have been written to emphasize the crosstalk between two or more systems. The chapters are well written with reasonably up-to-date references (always a problem in a multiauthored book). Illustrations and tables have been included where they serve a good purpose but there are not many. An unusual feature is a list of the authors of the references at the end of each chapter with the page where the reference appears, making it possible to find the context in which an investigator has been referenced.
Assessment: This is a unique set that presents an examination of the relationship between the immune/inflammatory, behavioral, neural, and endocrine systems. How these various systems interact needs to be defined so that better strategies for therapeutic intervention can be developed. The chapters are of high quality and full of information that indicates that no longer can these systems be considered separate and distinct.
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Product Details

  • ISBN-13: 9780080465012
  • Publisher: Elsevier Science
  • Publication date: 10/10/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 4
  • Pages: 1320
  • File size: 11 MB
  • Note: This product may take a few minutes to download.

Table of Contents

Exploring the Phylogenetic History of Neural-Immune System Interactions: An Update.

Section I. Neural and Endocrine Effects on Immunity.
Glucocorticoids and immunity: Mechanisms of regulation.
Adrenergic Regulation of Immunity.
Cholinergic Regulation of Inflammation.
Significance of Sensory Neuropeptides and the Immune Response.
Vasoactive Intestinal Peptide: An Anti-Inflammatory Neuropeptide.
Immune-Derived Opioids: Production and Function in Inflammatory Pain.
Crosstalk Between Insulin-Like Growth Factors and Proinflammatory Cytokines.
The Neuroendocrine System and Rheumatoid Arthritis: Focus on the Hypothalamic-Pituitary-Adrenal Axis.
Sex Steroids and Immunity.
Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuro-Endocrine-Immune Interactions and Evolutionary Biology
Neuroendocrine Regulation of Cancer Progression: Biological Mechanisms and Clinical Relevance.
Neuroendocrine regulation of cancer progression: II. Immunological mechanisms, clinical relevance, and prophylactic measures.

Section II: Immune System Effects on Neural and Endocrine Processes and Behavior.
Expression and Action of Cytokines in the Brain: Mechanisms and Pathophysiological Implications.
Cytokines, Sickness Behavior, and Depression.
The Differential Role of Prostaglandin E2 Receptors in the CNS Response to Systemic Immune Challenge.
The Role of Pro-Inflammatory Cytokines in Memory Processes and Neural Pasticity.
Aging, Neuroinflammation and Behavior.
Neuroimmune Interactions and Pain: The Role of Immune and Glial Cells.
Cytokines and Non-Immune Brain Injury.
The Interaction Between Brain Inflammation and Systemic Infection.

Section III: Behavior and Immunity.
Mother-Infant Interactions and the Development of Immunity from Conception through Weaning.
Social Dominance and Immunity in Animals.
Social Context as an Individual Difference in Psychoneuroimmunology.
Psychoneuroimmunology of Depressive Disorder: Mechanisms and Clinical Implications.
Immune and Neuroendocrine Alterations in Post Traumatic Stress Disorder.
Psychoneuroimmunologic Aspects of Alcohol and Substance Abuse.
Schizophrenia and Immunity.
Sleep and the Immune System.
Emotions and the Immune System.
Behaviorally Conditioned Enhancement of Immune Responses.
Exercise and Immunity: Clinical Studies
Behavioral Interventions: Immunologic Mediators and Disease Outcomes.

Section IV: Stress and Immunity.
Stress: A System of the Whole.
Bidirectional Effects of Stress on Immune Function: Possible Explanations for Salubrious as Well as Harmful Effects.
Positive Affect and Immune Function.
Close Relationships and Immunity.
Stress and Allergic Diseases.
Stress, Neuroendocrine Hormones, and Wound Healing: Human Models.
Stress and Wound Healing: Animal Models.
Reactivation of Latent Herpes Viruses in Astronauts.
Psychosocial Influences in Oncology: An Expanded Model of Biobehavioral Mechanisms.
Stress Associated Immune Dysregulation Can Effect Antibody and T-cell Responses to Vaccines.

Section V. Psychoneuroimmunology and Pathphysiology.
Psychoneuroimmunological Pathways Involved in Acute Coronary Syndromes.
Psychosocial Factors and Coronary Heart Disease: The Role of Psychoneuroimmunological Processes.
Endocrine and Immune Responses to Stress in Chronic Inflammatory Skin Disorder (Atopic Dermatitis).
Obesity and Immunity.
Endogenous Extracellular Hsp72 Release is an Adaptive Feature of the Acute Stress Response
Cold-Restraint-Induced Immune and Biochemical Changes Inhibit Host Resistance to Listeria.
Psychobiology of HIV Infection.
Stress-Induced Modulation of the Immune Response To Herpes Simplex Virus Infections.
Stress-Induced Modulation of Innate Resistance and Adaptive Immunity to Influenza Viral Infection.
Social Stress Alters the Severity of a Virally Initiated Model of Multiple Sclerosis.
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