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Pulmonary hypertension is increasingly diagnosed worldwide and is now recognized as a public health problem.
Pulmonary Hypertension investigates the etiology of pulmonary hypertension, including pathobiological aspects of the disease arid the proximity of PH to cancer, as well as the consequences severe PH leading to heart failure and death.
Pulmonary Hypertension is now recognized as a public health problem, not just as an orphan disease. Therefore, the thoughts, ideas, and practices in the field of Pulmonary Hypertension research merit careful consideration.
The authors highlight Facts and findings that underpin current pathogenetic concepts of PH, offering analysis and synthesis of the state-of-the art knowledge, using, in some instances, pre-PubMed original data. This research is necessary now, more than ever before, because of a-widespread belief that significant progress has been made in PH response.
The authors of this book challenge the belief that enough has been done and offer a means of making the history of pulmonary hypertension research available to the next generation by providing analysis of a large amount of data and offering new contexts for consideration of PH.
High-quality color photographs and color illustrations
World-renowned experts in their fields
Wide-ranging scope serving healthcare practitioners at every level
1 The Wide Spectrum of Pulmonary Vascular Diseases: "The Sick Lung Circulation" Norbert F. Voelkel 1
2 Mechanisms of Lung Vascular Remodeling Norbert F. Voelkel 11
3 Ion Channels and Transporters in Pulmonary Arterial Hypertension Thenappan Thenappan Lin Piao Jalees Rehman Stephen L. Archer 19
4 Reconciling Matrix Remodeling and Vasoconstriction in Pulmonary Hypertension Peter Lloyd Jones 51
5 The Immune Response in Pulmonary Hypertension Yon K. Sung Mark R. Nicolls 67
6 The Pathobiology of the Complex Vascular Lesions in Severe Pulmonary Hypertension-Angiogenesis and Cancer Norbert F. Voelkel Carlyne D. Cool 87
7 Pulmonary Veno-Occlusive Disease David Montani Dermot S. O'Callaghan Marc Humbert 105
8 Left Heart-Related Pulmonary Venous Hypertension Julio Sandoval Arturo Carrillo Felipe Massó Virgilia Soto Rodolfo Barragán Tomás Pulido Valentin Herrera Efrén Santos Norbert Voelkel 119
9 Pulmonary Hypertension and Interstitial Lung Disease Laszlo Farkas Martin R.J. Kolb 141
10 Animal Models of Pulmonary Hypertension Norbert F. Voelkel 161
11 Right Heart Failure in Pulmonary Hypertension Herman J. Bogaard Ramesh Natarajan Jose Gomez-Arroyo Antonio Abbate Norbert F. Voelkel 177
12 Genetics of Severe Pulmonary Hypertension Rajiv D. Machado Richard C. Trembath Nicholas W. Morrell 197
13 Pulmonary Hypertension in Children Christian Apitz Dietmar Schranz 211
14 Endocrine Aspects of Pulmonary Hypertension Lori B. Sweeney Laveena Chhatwani 239
15 The Role of Exercise in the Prognosis, Diagnosis and Management of Pulmonary Arterial Hypertension Daniel C. Grinnan Ross Arena Herman J. Bogaard 251
16 Treatment Strategies for Severe PAH: The Present and Future Dermot S. O'Callaghan Marc Humbert Gérald Simormeau 269
17 Inhaled Drugs for the Treatment of Pulmonary Hypertension: Challenges and Benefits Peter R. Byron Masahiro Sakagami 281
18 Biomarkers, Registries, and Outcomes R. Paul Fairman 301
19 On the Pathobiology and Treatment of Cancer and Pulmonary Arterial Hypertension Roland Mertelsmann Ralph Wäsch 317