Pulmonary Hypertension / Edition 1

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Pulmonary hypertension is increasingly diagnosed worldwide and is now recognized as a public health problem.

Pulmonary Hypertension investigates the etiology of pulmonary hypertension, including pathobiological aspects of the disease arid the proximity of PH to cancer, as well as the consequences severe PH leading to heart failure and death.

Pulmonary Hypertension is now recognized as a public health problem, not just as an orphan disease. Therefore, the thoughts, ideas, and practices in the field of Pulmonary Hypertension research merit careful consideration.

The authors highlight Facts and findings that underpin current pathogenetic concepts of PH, offering analysis and synthesis of the state-of-the art knowledge, using, in some instances, pre-PubMed original data. This research is necessary now, more than ever before, because of a-widespread belief that significant progress has been made in PH response.

The authors of this book challenge the belief that enough has been done and offer a means of making the history of pulmonary hypertension research available to the next generation by providing analysis of a large amount of data and offering new contexts for consideration of PH.

Key Features:

High-quality color photographs and color illustrations

World-renowned experts in their fields

Wide-ranging scope serving healthcare practitioners at every level

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Product Details

  • ISBN-13: 9781607950370
  • Publisher: PMPH-USA, Limited
  • Publication date: 5/1/2011
  • Edition number: 1
  • Pages: 350
  • Product dimensions: 7.20 (w) x 10.20 (h) x 0.80 (d)

Meet the Author

J&P Voelkel
Jon Voelkel grew up in Peru, Costa Rica and Colombia. He was not a natural-born adventurer and found life in the jungle difficult, to say the least. Having survived monkey stew, an attack by giant rats, and a plane crash in the middle of the rainforest, he escaped to college in Minneapolis and went on to business school in Barcelona. After working in advertising agencies in Spain, Holland and England, he started his own agency in London with four other partners - one of whom would be his future wife. In 2001, the London Financial Times named him one of the top fifty creative minds in Britain.
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Table of Contents

Contributors vii

Acknowledgments xi

Introduction xiii

1 The Wide Spectrum of Pulmonary Vascular Diseases: "The Sick Lung Circulation" Norbert F. Voelkel 1

2 Mechanisms of Lung Vascular Remodeling Norbert F. Voelkel 11

3 Ion Channels and Transporters in Pulmonary Arterial Hypertension Thenappan Thenappan Lin Piao Jalees Rehman Stephen L. Archer 19

4 Reconciling Matrix Remodeling and Vasoconstriction in Pulmonary Hypertension Peter Lloyd Jones 51

5 The Immune Response in Pulmonary Hypertension Yon K. Sung Mark R. Nicolls 67

6 The Pathobiology of the Complex Vascular Lesions in Severe Pulmonary Hypertension-Angiogenesis and Cancer Norbert F. Voelkel Carlyne D. Cool 87

7 Pulmonary Veno-Occlusive Disease David Montani Dermot S. O'Callaghan Marc Humbert 105

8 Left Heart-Related Pulmonary Venous Hypertension Julio Sandoval Arturo Carrillo Felipe Massó Virgilia Soto Rodolfo Barragán Tomás Pulido Valentin Herrera Efrén Santos Norbert Voelkel 119

9 Pulmonary Hypertension and Interstitial Lung Disease Laszlo Farkas Martin R.J. Kolb 141

10 Animal Models of Pulmonary Hypertension Norbert F. Voelkel 161

11 Right Heart Failure in Pulmonary Hypertension Herman J. Bogaard Ramesh Natarajan Jose Gomez-Arroyo Antonio Abbate Norbert F. Voelkel 177

12 Genetics of Severe Pulmonary Hypertension Rajiv D. Machado Richard C. Trembath Nicholas W. Morrell 197

13 Pulmonary Hypertension in Children Christian Apitz Dietmar Schranz 211

14 Endocrine Aspects of Pulmonary Hypertension Lori B. Sweeney Laveena Chhatwani 239

15 The Role of Exercise in the Prognosis, Diagnosis and Management of Pulmonary Arterial Hypertension Daniel C. Grinnan Ross Arena Herman J. Bogaard 251

16 Treatment Strategies for Severe PAH: The Present and Future Dermot S. O'Callaghan Marc Humbert Gérald Simormeau 269

17 Inhaled Drugs for the Treatment of Pulmonary Hypertension: Challenges and Benefits Peter R. Byron Masahiro Sakagami 281

18 Biomarkers, Registries, and Outcomes R. Paul Fairman 301

19 On the Pathobiology and Treatment of Cancer and Pulmonary Arterial Hypertension Roland Mertelsmann Ralph Wäsch 317

Epilogue 341

Index 345

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