Quality in Laboratory Hemostasis and Thrombosis / Edition 1

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The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing.

Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.

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Editorial Reviews

From the Publisher
"There are particularly useful chapters covering the monitoring of heparin and oral anticoagulation. The book is pretty up to date and even covers the monitoring of new anticoagulants." (The Bulletin of the Royal College of Pathologists, July 2010)
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Product Details

  • ISBN-13: 9781405168038
  • Publisher: Wiley
  • Publication date: 1/20/2009
  • Edition number: 1
  • Pages: 232
  • Product dimensions: 7.60 (w) x 9.80 (h) x 0.90 (d)

Meet the Author

Eric Preston MD, FRCP, FRCPath
Professor Preston is Emeritus Professor of Haematology at the University of Sheffield since 2000, having been Professor of Haematology in the same University from 1986 – 2000. He was Director of the Sheffield Haemostasis and Thrombosis Centre from 1973 – 2000. He is a past President of the British Society for Haematology and also the British Society for Haemostasis and Thrombosis. During the period 1992 – 2005 he was Director of the UK National External Quality Assessment Scheme (UKNEQAS) for Blood Coagulation. He continues as Director of the WHO International External Quality Assessment Program for Blood Coagulation testing for Developing Countries and also as Director of the World Federation of Hemophilia (WFH) Blood Coagulation EQA program. Professor Preston has been a co-author on more than 250 publications in peer reviewed journals in the field of hemostasis and thrombosis. He is currently vice chairman of the newly formed international group devoted to EQA in hemostasis and thrombosis EQATH).

Steve Kitchen PhD
Dr Steve Kitchen is currently the Scientific Director of the UK National External Quality Assessment Scheme for Blood Coagulation and is the Head Scientist for the WHO and World Federation of Haemophilia EQA programmes . He is the head scientist at the Sheffield Haemostasis and Thrombosis Centre. He has 25 years experience in the field of laboratory testing in haemostasis with a long standing interest in standardisation and has been involved in drawing up guidelines for a number of National and International bodies in the field.

John D. Olson, MD, PhD
Dr Olson is Professor of Pathology at the University of Texas Health Science Center at San Antonio and Director of Clinical Laboratories for the University Health Systems. He has had a continuing interest in haemostasis and thrombosis that has spanned his career of more than 30 years. Recently, he was the Chair of the Coagulation Resource Committee (1999 to 2004) of the College of American Pathologists. This committee a the largest external quality assurance program in haemostasis in North America. He has spoken at national and international meetings on the topic of quality in haemostasis. He is currently the chair of a newly formed international group of programs devoted to external quality assurance in haemostasis and thrombosis (EQATH).

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Table of Contents

Contributors vii

Foreword Frits R. Rosendaal x

Preface xii

1 General Quality Planning in the Hemostasis Laboratory John D. Olson 1

2 Hemostasis Test Validation, Performance and Reference Intervals Richard A. Marlar 9

3 International Standards in Hemostasis Trevor W. Barrowcliffe 19

4 Sample Integrity and Preanalytical Variables Dorothy M. Adcock 31

5 Internal Quality Control in the Hemostasis Laboratory Steve Kitchen F. Eric Preston John D. Olson 43

6 External Quality Assessment in Hemostasis: Its Importance and Significance F. Eric Preston Steve Kitchen Alok Srivastava 51

7 Initial Evaluation of Hemostasis: Reagent and Method Selection Wayne L. Chandler 63

8 Point-of-Care Testing in Hemostasis Chris Gardiner Samuel Machin Ian Mackie 72

9 Assay of Factor VIII and Other Clotting Factors Steve Kitchen F. Eric Preston 81

10 Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders Stefan Lethagen Marianne Schwartz Lars Bo Nielsen 90

11 Standardization of D-dimer Testing Guido Reber Philippe de Moerloose 99

12 Diagnostic Assessment of Platelet Function Paquita Nurden Alan Nurden 110

13 Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis Emmanuel J. Favaloro 125

14 Laboratory Analysis of von Willebrand Disease: Molecular Analysis Anne Goodeve Ian Peake 137

15 Dilemmas in Heritable Thrombophilia Testing Isobel D. Walker Ian Jennings 147

16 Evaluation of Antiphospholipid Antibodies Michael Greaves 160

17 Monitoring Heparin Therapy Marilyn Johnston 170

18 Monitoring Oral Anticoagulant Therapy Armando Tripodi 179

19 Monitoring New Anticoagulants Elaine Gray Trevor W. Barrowcliffe 190

20 Detecting and Quantifying Functional Inhibitors in Hemostasis Bert Verbruggen Irena Nováková Waander van Heerde 198

Index 209

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