Quantitative Cyto- and Histoprognosis in Breast Cancer

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Product Details

  • ISBN-13: 9780444893741
  • Publisher: Elsevier Science
  • Publication date: 1/1/1992
  • Pages: 212

Table of Contents

Prognostic factors in breast cancer 3
Pt. I Cytomorphometric aspects
Cytomorphometry: A Methodologic study on preparation techniques, selection methods and sample sizes 35
Comparison of lightmicroscopic grading and morphometric features in cytological breast cancer specimens 47
Prognostic value of nucleolar morphometric variables in cytological breast cancer specimens 55
Pt. II Histomorphometric and morphologic aspects
The morphometric multivariate prognostic index (MPI) is the strongest prognosticator in premenopausal lymph node negative and lymph node positive breast cancer patients 65
Prognostic value of proliferation in lymph node metastases of breast cancer patients 75
An expert system for histologic typing and grading of invasive breast cancer: First setup 83
Pt. III Syntactic structure analysis
Syntactic structure analysis: An introduction 93
Reproducibility and prognostic value of syntactic structure analysis in invasive breast cancer 99
The biological background of syntactic structure parameters: An evaluation of correlations with and additional prognostic value to classic, morphometric and DNA cytometric features in invasive breast cancer 108
Pt. IV Quantitation of neu-oncoprotein expression
Quantitation of HER-2/neu oncoprotein overexpression in invasive breast cancer by image analysis: A study comparing fresh and paraffin-embedded material 119
Comparative long-term prognostic value of quantitative HER-2/neu protein expression, DNA ploidy, morphometric and clinical features in paraffin-embedded invasive breast cancer 128
Prediction of response to adjuvant chemotherapy in premenopausal lymph node positive breast cancer patients with morphometry, DNA flow cytometry and HER-2/neu oncoprotein expression: Preliminary results 143
Pt. V The multicenter morphometric mammary carcinoma project
The multicenter morphometric mammary carcinoma project. A nationwide prospective study on reproducibility and prognostic power of routine quantitative assessments in the Netherlands 157
Data processing and analysis in the multicenter morphometric mammary carcinoma project (MMMCP) 168
Reproducibility of mitosis counting in 2469 breast cancer specimens: Results from the multicenter morphometric mammary carcinoma project 179
Pt. VI General discussion, future prospects and summary
General discussion 193
Future perspectives in breast cancer 197
Summary 202
Subject index 207
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