Quantitative Molecular Pharmacology and Informatics in Drug Discovery / Edition 1

Quantitative Molecular Pharmacology and Informatics in Drug Discovery / Edition 1

by Michael Lutz, Terry Kenakin
     
 

Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to

See more details below

Overview

Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide.
* outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and,
* provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays.
Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.

Read More

Product Details

ISBN-13:
9780471988618
Publisher:
Wiley
Publication date:
01/11/2000
Pages:
428
Product dimensions:
6.22(w) x 9.45(h) x 1.12(d)

Table of Contents

Drug Discovery.

Measurement of Drug Affinity.

Efficacy.

Pharmacological Assays Used in Screening for Therapeutic Ligands.

Finding the Optimal Assay Format for the Chemical Target.

Mathematical and Statistical Framework for Problems in Drug Discovery.

Statistical Methods for Target Identification and Validation.

Experimental Design.

Analysis and Interpretation of Data.

Index.

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >