Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens

by Romualdo Benigni (Editor)

Overview

Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals.
This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on

Product Details

ISBN-13:	9781135505691
Publisher:	CRC Press
Publication date:	02/26/2003
Sold by:	Barnes & Noble
Format:	eBook
Pages:	304
File size:	5 MB

About the Author

Romualdo Benigni

Table of Contents

General Introduction to QSAR. Mechanisms of Action of Chemical Carcinogens and their Role in Structure-Activity Relationships (SAR) Analysis and Risk Assessment. QSARs for Individual Classes of Chemical Mutagens and Carcinogens. QSARs for the Mutagenicity and Carcinogenicity of the Aromatic Amines. SAR in the Assessment of Carcinogenesis: the Multicase Approach. Predicting Mutagenicity of Congeneric and Diverse Sets of Chemicals Using Computed Molecular Descriptors: A Hierarchical Approach. Quantitative Structure-Activity Relationships for Acute Aquatic Toxicity: The Role of Mechanisms of Toxic Action in Successful Modelling. SARs and QSARs of Mutagens and Carcinogens: Understanding Action Mechanisms and Improving Risk Assessment.

Editorial Reviews

"[T]he editor has assembled a first-rate team of contributors who are themselves active in the field … . … I can certainly recommend this volume on the basis of the information it contains … . "
- Journal of Medicinal Chemistry, 2004, Vol. 47, No. 21

From the Publisher