The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

by Brent R. Stockwell
     
 

ISBN-10: 0231152124

ISBN-13: 9780231152129

Pub. Date: 06/01/2011

Publisher: Columbia University Press

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we may be reaching the end of drug discovery to combat major diseases. In this engaging book, Brent Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the

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Overview

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we may be reaching the end of drug discovery to combat major diseases. In this engaging book, Brent Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, the book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and describes cellular and molecular barriers thwarting scientists who use tools from traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities& mdash;technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules& mdash;all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest underway to develop a new generation of cures.

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Product Details

ISBN-13:
9780231152129
Publisher:
Columbia University Press
Publication date:
06/01/2011
Pages:
284
Product dimensions:
5.70(w) x 8.40(h) x 1.10(d)
Age Range:
18 Years

Table of Contents

List of Illustrations xi

Preface xiii

Acknowledgments xv

Abbreviations xvii

Part 1 The Vanishing Cures

1 The Drug Discovery Crisis 3

2 A New Science of Molecules 24

3 The Birth of the First Cancer Drugs 45

4 A New Company Creating Drug Combinations 66

5 The Undruggable RAS Protein 81

6 The Druggable Genome 101

Part 2 The Path to the Next Generation of Medicines

7 Peering Inside Proteins 119

8 The Nature of Interactions Between Proteins 139

9 From Protein-Protein Interactions to Personalized Medicines 156

10 A Revolution in Peptide Synthesis 169

11 A Vast Array of Drug Candidates 185

12 Moving Outside the Small Molecule Box 205

13 Acceleratingthe Arrival of Next-Generation Drugs 224

Notes 229

Glossary 251

Index 255

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