Quinolone Antimicrobial Agents / Edition 2

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An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years.
• Compiles the current information on a larger number of compounds and their expanding clinical applications.
• Provides a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical communities.
• Includes information on the treatment of intra-abdominal infections and infections caused by intracellular pathogens and the use of fluoroquinolones in intensive care unit infections and in pediatrics.
• Covers adverse effects, including QT prolongation, phototoxicity, effects on cartilage, and central nervous system effects.

Includes structure-activity relationships, quinolone- DNA interaction, trmt of eye infections, veterinary use, etc

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Editorial Reviews

A summary of the problems and promises that quinolones hold for the scientific and clinical communities. This revised, updated, and expanded edition (1st ed., 1989) brings together current information on a larger number of compounds and their expanding clinical applications as well as new information on the limitations to the use of quinolones, including problems with bacterial resistance and new adverse-effect profiles of some quinolones. For clinical and basic microbiologists, pharmacologists and pharmacists, and physicians--especially infectious disease specialists. Member price, $55. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781555810597
  • Publisher: ASM Press
  • Publication date: 10/28/1993
  • Edition description: REV
  • Edition number: 2
  • Pages: 549

Table of Contents

I Mechanisms and Spectrum of Antibacterial Activity and Resistance
1 Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not 3
2 Mechanisms of Quinolone Action 19
3 Mechanisms of Quinolone Resistance 41
4 Quinolones and Eukaryotic Topoisomerases 69
5 Activity In Vitro of the Quinolones 91
II Pharmacology
6 Pharmacokinetics of Fluoroquinolones 115
7 Drug-Drug Interactions 133
8 Pharmacodynamics of Quinolone Antimicrobial Agents 147
III Clinical Applications
9 Treatment of Urinary Tract Infections 159
10 Use of Quinolones for Treatment of Sexually Transmitted Diseases 171
11 Treatment and Prophylaxis of Gastroenteritis 193
12 Treatment of Intra-Abdominal Infections 217
13 Treatment of Community-Acquired Respiratory Tract Infections 227
14 Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage 245
15 Treatment of Osteomyelitis and Septic Arthritis 251
16 Treatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial Agents 259
17 Treatment of Bacterial Meningitis and Other Central Nervous Systems Infections 275
18 Treatment of Eye Infections 291
19 Treatment of Skin and Soft Tissue Infections 311
20 Treatment of Intracellular Infections 323
21 Fluoroquinolones in Intensive Care Unit Infections 337
22 Quinolones in Pediatrics 343
23 Quinolone Resistance and Its Clinical Relevance 355
24 Veterinary Use of Quinolones and Impact on Human Infections 387
IV Adverse and Other Effects
25 Adverse Effects 407
26 QT Prolongation with Quinolone Antimicrobial Agents 421
27 Effects on Connective Tissue Structures 441
28 Phototoxicity Due to Fluoroquinolones 451
29 Central Nervous System Toxicity 461
30 Effects of Quinolones on the Immune System 467
Index 475
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