Quinolone Antimicrobial Agents

Overview

An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years.
• Compiles the current information on a larger number of compounds and their expanding clinical applications.
• Provides a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical communities.
• Includes information on the...
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Overview

An in-depth review of one of the most important classes of antimicrobial agents discovered in recent years.
• Compiles the current information on a larger number of compounds and their expanding clinical applications.
• Provides a knowledgeable summary of the problems and promises that quinolones hold for the scientific and clinical communities.
• Includes information on the treatment of intra-abdominal infections and infections caused by intracellular pathogens and the use of fluoroquinolones in intensive care unit infections and in pediatrics.
• Covers adverse effects, including QT prolongation, phototoxicity, effects on cartilage, and central nervous system effects.

Includes structure-activity relationships, quinolone- DNA interaction, trmt of eye infections, veterinary use, etc

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Editorial Reviews

Booknews
A summary of the problems and promises that quinolones hold for the scientific and clinical communities. This revised, updated, and expanded edition (1st ed., 1989) brings together current information on a larger number of compounds and their expanding clinical applications as well as new information on the limitations to the use of quinolones, including problems with bacterial resistance and new adverse-effect profiles of some quinolones. For clinical and basic microbiologists, pharmacologists and pharmacists, and physicians--especially infectious disease specialists. Member price, $55. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781555812317
  • Publisher: ASM Press
  • Publication date: 9/30/2003
  • Edition description: Revised
  • Edition number: 3
  • Pages: 485
  • Product dimensions: 8.70 (w) x 11.24 (h) x 1.17 (d)

Table of Contents

Table of Contents

Section I. Mechanisms and Spectrum of Antibacterial Activity and Resistance

1. Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Changes and Some Do Not
2. Mechanisms of Quinolone Action
3. Mechanisms of Quinolone Resistance
4. Quinolones and Eukaryotic Topoisomerases
5. Activity in Vitro of the Quinolones
Section II. Pharmacology

6. Pharacokinetics of Fluoroquinolones
7. Drug-Drug Interactions
8. Pharmacodynamics of Quinolone Antimicrobial Agents
Section III. Clinical Applications

9. Treatment of Urinary Tract Infections
10. Use of Quinolones for Treatment of Sexually Transmitted Diseases
11. Treatment and Prophylaxis of Gastroenteritis
12. Treatment of Intra-Abdominal Infections
13. Treatment of Community-Acquired Respiratory Tract Infections
14. Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage
15. Treatment of Osteomyelitis and Septic Arthritis
16. Treatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial Agents
17. Treatment of Bacterial Meningitis and Other Central Nervous Systems Infections
18. Treatment of Eye Infections
19. Treatment of Skin and Soft Tissue Infections
20. Treatment of Intracellular Infections
21. Fluoroquinolones in Intensive Care Unit Infections
22. Quinolones in Pediatrics
23. Quinolone Resistance and Its Clinical Relevance
24. Veterinary Use of Quinolones and Impact on Human Infections
Section IV. Adverse and Other Effects

25. Adverse Effects
26. QT Prolongation with Quinolone Antimicrobial Agents
27. Effects on Connective Tissue Structures
28. Phototoxicity Due to Fluoroquinolones
29. Central Nervous System Toxicity
30. Effects of Quinolones on the Immune System

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