Radical and Radical Ion Reactivity in Nucleic Acid Chemistry / Edition 1

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry / Edition 1

by Michael D. Greenberg
     
 

Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry

The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging

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Overview

Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry

The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.

The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.

With contributions by world leaders in the field, the text covers a broad range of topics, including:

  • A discussion of the relevent theory
  • Ionization of DNA
  • Nucleic acid sugar radicals
  • Nucleobase radicals
  • Halopyrimidines
  • Oxidative, reductive, and low energy electron transfer
  • Electron affinity sensitizers
  • Photochemical generative of reactive oxygen species
  • Reactive nitrogen species
  • Electrochemical oxidation of nucleic acids
  • Enediyne rearrangements
  • DNA photochemistry
  • Phenoxyl radicals

A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

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Product Details

ISBN-13:
9780470255582
Publisher:
Wiley
Publication date:
10/05/2009
Series:
Wiley Series of Reactive Intermediates in Chemistry and Biology Series, #5
Pages:
480
Product dimensions:
6.30(w) x 9.30(h) x 1.10(d)

Table of Contents

Preface to Series vii

Introduction ix

Contributors xi

1. Theoretical Modeling of Radiation-Induced DNA Damage 1
Anil Kumar and Michael D. Sevilla

2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41
William A. Bernhard

3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69
Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. Richard Wagner

4. Reactivity of Nucleic Acid Sugar Radicals 99
Chryssostomos Chatgilialoglu

5. Pyrimidine Nucleobase Radical Reactivity 135
Marc M. Greenberg

6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163
Ryu Tashiro and Hiroshi Sugiyama

7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191
Kiyohiko Kawai and Tetsuro Majima

8. Radical Intermediates During Reductive Electron Transfer Through DNA 211
Reji Varghese and Hans-Achim Wagenknecht

9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239
Leon Sanche

10. Electronic-Affinic Radiosensitizers 295
Peter Wardman

11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325
Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov

12. Principles and Applications of Electrochemical Oxidation of Nucleic Acids 357
H. Holden Thorp and Julie M. Sullivan

13. DNA Damage Due to Diradical-Generating Cyclizations 389
Sean M. Kerwin

14. DNA Damage by Phenoxyl Radicals 421
Richard A. Manderville

Index 445

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