"Rappaccini's Daughter" is a short story by Nathaniel Hawthorne published in the 1844 collection Mosses from an Old Manse. It is about Giacomo Rappaccini, a medical researcher in medieval Padua who grows a garden of poisonous plants. He brings up his daughter to tend the plants, and she becomes resistant to the poisons, but in the process she herself becomes poisonous to others. The traditional story of a poisonous maiden has been traced back to India, and Hawthorne's version has been adopted in contemporary works.
The story is set in Padua, Italy, in a distant and unspecified past. From his quarters, Giovanni Guasconti, a young student of letters, looks at Beatrice, the beautiful daughter of Dr. Giacomo Rappaccini, a scientist who works in isolation. Beatrice is confined to the lush and locked gardens, which are filled with poisonous plants grown by her father. Giovanni notices Beatrice's strangely intimate relationship with the plants as well as the withering of fresh flowers and the death of an insect when exposed to her skin or breath. Having fallen in love, Giovanni enters the garden and meets with Beatrice a number of times, ignoring his mentor, Professor Pietro Baglioni, who warns him that Rappaccini is up to no good and that he and his work should be avoided. Giovanni discovers that Beatrice, having been raised in the presence of poison, is poisonous herself. Beatrice urges Giovanni to look past her poisonous exterior and see her pure and innocent essence, creating great feelings of doubt in Giovanni. He begins to suffer the consequences of his encounters with the plants - and with Beatrice - when he discovers that he himself has become poisonous; after another meeting with Baglioni, Giovanni brings a powerful antidote to Beatrice so that they can be together, but the antidote kills Beatrice rather than getting rid of her poisonous nature.