Reactive Oxygen Metabolites: Chemistry and Medical Consequences

by Manfred K. Eberhardt

Overview

In recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its findings are having enormous impact in a broad range of disciplines, and we now have evidence for radical involvement in over 100 diseases. As important as this is, however, the subject of radicals and

Product Details

ISBN-13:	9781040201114
Publisher:	CRC Press
Publication date:	07/21/2000
Sold by:	Barnes & Noble
Format:	eBook
Pages:	608
File size:	2 MB

Table of Contents

The Pros and Cons of Living in an Oxygen Atmosphere. Basic Chemistry of Radicals. Chemistry of Oxygen-Derived Radicals. Chemistry of Electronically Excited States. Formation of Reactive Oxygen Metabolites in Vivo. Reactions of Reactive Oxygen Metabolites with Important Biomolecules. Nitric Oxide. Antioxidants. Pathological Processes Involving Reactive Oxygen Metabolites. Conclusion. References.

Editorial Reviews

For people who want to know about the importance of reactive oxygen and nitrogen species in human health but do not have the time, inclination, or background to work their way through the vast original literature, organic chemist (pathology and laboratory medicine, U. of Puerto Rico-San Juan) introduces the metabolites with an emphasis on their chemistry. First he weighs the pros and cons of living in an oxygen atmosphere, then explores the basic chemistry of radicals in general and those derived from oxygen in particular, the chemistry of electronically excited states, the formation of reactive oxygen metabolites reactions of the metabolites with important biomolecules, nitric oxide, antioxidants, and pathological processes involving reactive oxygen metabolites. His bibliography contains over 1,500 references. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

"The author discusses the basic chemistry of reactive oxygen metabolites with great expertise and then applies this knowledge to the analysis of pathological processes. It is a treasure trove of information, but does not overwhelm and is fun to read. Due to the ever increasing importance of reactive oxygen metabolites, this text should be required reading in medical schools."
—Angel A. Roman Franco, M.D.
"…To write a single-authored, compact introductory text which encompasses all the different aspects of ROM chemistry, biology and pathology is a challenging task: the author has succeeded formidably…The text is throughout well referenced. It not only represents an easy to read overview of this complex interdisciplinary subject of biological and medical relevance, but serves also as a fountain of valuable information for more in-depth considerations. As an introductory text, this book should have wide appeal and is highly recommended. It should be a welcomed text for a special topic course at the interphase of chemistry, biology and medicine: I certainly would adopt it for my course at the advanced undergraduate and graduate level."
- Prof. Dr. W. Adam, Institut für Organische Chemie der Universität Würzburg

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