Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis

by Sosale Chandrasekhar

Overview

Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction.The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included. - Summarizes mechanistic background with an emphasis on synthetic applications - Includes up-to-date references that allow for locating original papers for experimental procedures - Provides applications in the synthesis of complex molecules and natural products to judge the scope and limitations of each reaction

Product Details

ISBN-13:	9780128237441
Publisher:	Elsevier Science
Publication date:	10/09/2024
Sold by:	Barnes & Noble
Format:	eBook
Pages:	300
File size:	64 MB
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About the Author

Sosale Chandrasekhar was born on 25 April 1952; he earned his MSc from IIT Bombay, his PhD from the University of London, and his Postdoc from Cambridge University, Max-Planck Institute and Muelheim/Ruhr, University of Montreal. He taught at Indian Institute of Science Bangalore since 1984, and as Professor from 2003 onwards, and retired in 2017. His research interests include synthetic and mechanistic organic chemistry, stereochemistry and biological applications.

Table of Contents

Part I. The Beckmann RearrangementPart II. The Hoffmann and Related Rearrangements1. Introduction (historical and current status)Mechanistic backgroundReactions and MethodologyScope and ApplicationsReferences2. (Curtius) Introduction (historical and current status)Mechanistic backgroundReactions and MethodologyScope and ApplicationsReferences3. (Lossen) Introduction (historical and current status)Mechanistic backgroundReactions and MethodologyScope and ApplicationsReferencesPART III. The Baeyer-Villiger ReactionIntroduction (historical and current status)Mechanistic backgroundReactions and MethodologyScope and ApplicationsReferences

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From the Publisher

Covers the basic principles and synthetic applications of a critically important class of organic reactions