Recombinant Technology in Hemostasis and Thrombosis

Paperback (Softcover reprint of the original 1st ed. 1991)
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Editorial Reviews

Reviews the impact of recombinant DNA technology on the study of proteins that are essential for hemostasis and thrombosis. The 18 papers discuss the characterization of the relevant gene and protein structures, molecular defects affecting hemostasis, the production of proteins by recombinant technology, and the clinical use of such proteins. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781461366447
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Edition description: Softcover reprint of the original 1st ed. 1991
  • Edition number: 1
  • Pages: 261
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.57 (d)

Table of Contents

Characterization of Gene and Protein Structure.- Biosynthesis and Assembly of the Factor VIII-von Willebrand Factor Complex.- Factor IX: Gene Structure and Protein Synthesis.- Antithrombin III Genetics, Structure and Function.- Interactions Between the Functional Domains of Antithrombin III.- Protein C: Gene Structure and Protein Synthesis.- Structural and Functional Properties of Protein C.- Molecular Defects Affecting Hemostasis.- Molecular Defects in Hemophilia A.- Molecular Defects in Hemophilia B.- Molecular Defects in Human Antithrombin III Deficiency.- The Biologic Impact of Hereditary Defects that Cause Thrombosis.- Protein Production by Recombinant Technology.- Factors Limiting Expression of Secreted Proteins in Mammalian Cells.- Synthesis of Biologically Active Vitamin K-Dependent Coagulation Factors.- The Expression of Therapeutic Proteins in Transgenic Animals.- Clinical use of Proteins Produced by Recombinant Technology.- The Use of Animal Models to Evaluate Proteins Produced by Recombinant Technology.- Experiences with Recombinant Factor VIIa in Hemophiliacs.- Clinical Trials of Factor VIII Produced by Recombinant Technology.- Clinical Trials of Recombinant Factor VIII.- Concluding Overview.- The Impact of Recombinant Technologies in Understanding Plasma Proteins Important for Hemostasis and Thrombosis.- Contributors.

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