Red Blood Cell Substitutes: Basic Principles and Clinical Applications: Basic Principles and Clinical Applications

by Alan Rudolph (Editor)

Overview

Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of

Product Details

ISBN-13:	9781040213353
Publisher:	CRC Press
Publication date:	09/05/1997
Sold by:	Barnes & Noble
Format:	eBook
Pages:	504
File size:	14 MB
Note:	This product may take a few minutes to download.

Table of Contents

Utilization - economic and regulatory issues: the impact of blood substitutes on blood banking world wide; potential use of red blood cells substitutes within the military; blood substitutes - unique regulatory aspects. Fundamental principles of oxygen transport : oxygen transport, oxygen carriers, and the transfusion trigger; microcirculatory consequences of blood substitutes with haemoglobin solutions; efficacy of perfluorocarbon-based emulsion as a temporary oxygen carrier; pathophysiology of oxygen utilization in haemorrhagic shock - studies with human recombinant haemoglobin. Interactions with organ systems: immunological alterations following haemorrhagic shock - considerations for resuscitation with blood substitutes; the effect of haemoglobin-based substitutes on kidney function; interactions of haemoglobin with the central nervous system. Interactions with molecular species: interactions between haemoglobin and bacterial endotoxin In Vitro and In Vivo. Alternative strategies and indications: encapsulation of haemoglobin in liposomes; the use of blood substitutes in tumour therapy; human haemoglobin derived from transgenic swine - a starting material for 'blood substitute' formulations. Clinical development: OptroTM (recombinant human haemoglobin) - a therapeutic for the delivery of oxygen and the restoration of blood volume in the treatment of acute blood loss in trauma and surgery; production, characterization, and clinical evaluation of hemolinkTM on o-raffinose cross-linked haemoglobin-based blood substitute; hemassistTM - development and clinical profile; the clinical development of human polymerized haemoglobin; oxypureTM - development of polymerized bovine haemoglobin; febluobronTM - development of an oxygen carrying perfluobronTM - development of an oxygen carrying perfluorocarbon. Future directions: future perspective of red cells substitutes.

Editorial Reviews

This book is a general yet comprehensive overview of historic and contemporary issues and research in red blood cell substitutes. It is intended to provide a comprehensive overview of current strategic fundamental programs and clinical development of red blood cell substitutes. This is a worthy objective and the book meets the editors' objectives. There is not a specified target audience, but I believe it would include practitioners who frequently confront issues of red blood cell transfusions. The editors and contributors are experts in their respective fields. Graphs of data are frequently busy but user friendly. Tables summarizing information would make the narrative easier to follow. A glossary would be helpful to define new terminology. The content is extremely timely and comprehensive. The fundamentals of cardiovascular and pulmonary physiology are explained comprehensively. The references are surprisingly current. I recommend this as an up-to-date reference for a medical library and those who encounter RBC transfusion on a frequent basis.

M. Geno Tellez

A comprehensive overview of the current strategies in hemoglobin-based blood substitutes, the fundamental properties of these products, and recent advances in clinical development. Following an examination of regulatory and socioeconomic aspects of blood substitute products and global transfusion practices, US and Canadian experts in academia, industry, and federal laboratories discuss the interactions of red cell substitutes with organ systems; the impact on human physiology; laboratory and clinical efforts to develop chemically modified, encapsulated, recombinant, and transgenic hemoglobin, in addition to fluorocarbon solutions; recent data from ongoing preclinical and clinical trials; safety issues; second-generation blood substitutes; and future directions. Annotation c. by Book News, Inc., Portland, Or.

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