The Red Cell Membrane: A Model for Solute Transport / Edition 1

by B. U. Raess, G. Tunnicliff

Overview

"After being frequently urged to write upon this subject, and as often declining to do it, from apprehension of my own inability, I am at length compelled to take up the pen, however unqualified I may still feel myself for the task. " William Withering, M. D. ' I have yet to find a description or a quote that better summanzes my initial ambivalence towards embarking on such an endeavor as partici­ pating in putting together this monograph. The impetus for The Red-Cell has been a simple, genuine Membrane: A Model for Solute Transport desire to bring together an authoritative account of the' 'state of the art and knowledge" in the red-ceIl-membrane transport field. In particular, it seems important to emphasize the pivotal role the red cell has played for several decades in the discovery and the elucidation of mechanisms of plasma-membrane transport processes. It is only with such knowledge that we can hope to push ahead and make progress in this exciting, multifaceted area. Eventually, one hopes to not only further our knowledge of red cells, but apply the newly gained insights to any other of the plasma membrane. cell with the common denominator In this compendium of reviews, the reader will find that the term model will take on a variety of gists and meanings. In some chapters, the red cell has been chosen as a model membrane solely on the basis of its preeminent design and simplicity.

Product Details

ISBN-13:	9780896031586
Publisher:	Springer-Verlag New York, LLC
Publication date:	01/16/1990
Series:	Contemporary Biomedicine , #10
Edition description:	1989
Pages:	476
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

1. Introduction.- Why Red Cells?.- Need and Applications of Integrated Red Cell Models.- 2. Biochemistry and Biophysics.- Molecular Structure of the Na,K,-ATPase.- Enzymatic and Functional Aspects of Na+/K+ Transport.- The (Ca2+ + Mg2+)-ATPase: Purification and Reconstitution.- Catalytic Mechanisms of the Ca-Pump ATPase.- Regulation of the Plasma Membrane Ca2+-Pump.- The Anion Transport Protein: Structure and Function.- Kinetics of Anion Transport.- Ca2+-Activated Potassium Channels.- Amino Acid Flux Across the Human Red Cell Plasma Membrane.- Hexose Transport Across Human Erythrocyte Membranes.- Chloride-Dependent Cation Transport in Human Erythrocytes.- 3. Pharmacology.- Pharmacological Modification of the Red Cell Ca2+-Pump.- Irreversible Modification of the Anion Transporter.- Drug Actions on Potassium Fluxes in Red Cells.- 4. Pathophysiology.- Membrane Lipid Changes in the Abnormal Red Cell.- Calcium Fluxes in Pathologically Altered Red Cells.- Mechanisms of Red Cell Dehydration in Sickle Cell Anemia: Application of an Integrated Red Cell Model.