Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Disease / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $52.34
Usually ships in 1-2 business days
(Save 77%)
Other sellers (Hardcover)
  • All (7) from $52.34   
  • New (4) from $173.39   
  • Used (3) from $52.34   


Methodology and applications of redox proteomics

The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:
* The role of oxidized proteins in various disorders
* Pioneering studies on the development of redox proteomics
* Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
* The response and regulation of protein oxidation in different cell types
* The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease

Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Alan Cahill, Ph.D.(Thomas Jefferson University)
Description: Redox proteomics is the branch of proteomics that identifies oxidatively modified proteins in order to gain insights into normal and abnormal functions of cells. Oxidative modifications of proteins accompany aging and are seen in many disease states. Since oxidative modifications inhibit protein function, the authors contend that identifying oxidatively modified proteins will provide essential insights into the molecular pathways of human disease. This book includes 27 chapters on topics ranging from "modification of proteins by reactive oxygen species" to "oxidation of artery wall proteins by myeloperoxidase." It is divided into three parts: part I describes chemical processes involved in the oxidation of proteins; part II covers redox proteomics in normal cell physiology and pharmacology; and part III describes applications of redox proteomics to various disease states. The focus of this book is on chemistry and cellular biochemistry.
Purpose: According to the editors, the aim of this book is to "provide researchers with new insights into normal and altered physiology, and molecular mechanisms of disease...and provide a core reference text for experts in cellular physiology and proteomics." The editors also believe that this book could serve as a basis for a graduate-level course in proteomics.
Audience: The book is written for research scientists interested in proteomics and oxidative metabolism or proteins. Clinicians interested in neurodegenerative diseases will also find this topic (redox proteomics) particularly fascinating and relevant to their field of study. Students and laboratory staff will appreciate the depth of focus and extensive lists of references. It provides a gateway to this new and exciting field and is written by leading experts for a wide audience interested in chemistry and biochemistry.
Features: This book provides an extensive collection of state-of-the-art redox proteomics methodologies, and serves as an informative guide to cellular mechanisms of protein oxidation. Each chapter provides an introduction, conclusion, and helpful list of abbreviations. The black/white illustrations and line drawings are well done. A key feature is the invaluable collection of references, which cover all aspects of oxidative protein modification. The final set of chapters make a convincing case for the important role of oxidative stress in the pathogenesis of a number of disease states.
Assessment: This is a very informative resource that is sure to draw attention to oxidative damage as a key mediator of disease and aging. This book provides detailed and extremely informative insights into cellular mechanisms of protein oxidation. It illustrates how state-of-the-art redox proteomics can be used to identify oxidatively-modified proteins in a number of specific disease states. Its extensive collection of references and expertise makes it an invaluable resource for established scientists, students, and laboratory personnel alike. Every laboratory that uses redox proteomics in both clinical and academic research should possess a copy of this excellent book.
From the Publisher
"...a major book...readers interested in mass spectrometry methods in proteomics will find much that is of interest here." (Journal of the American Society for Mass Spectrometry, March 2007)

"Every laboratory that uses redox proteomics in both clinical and academic research should possess a copy of this excellent book." (Doody's Health Services)

"…highly recommended as a reference text…Redox Proteomics is thought to be a milestone in this field…" (Biotechnology Journal, March 2007)

Read More Show Less

Product Details

  • ISBN-13: 9780471723455
  • Publisher: Wiley
  • Publication date: 6/12/2006
  • Series: Wiley Series on Mass Spectrometry Series, #9
  • Edition description: 1ST
  • Edition number: 1
  • Pages: 976
  • Product dimensions: 6.30 (w) x 9.33 (h) x 1.94 (d)

Meet the Author

ISABELLA DALLE-DONNE, PHD, is Assistant Professor in the Department of Biology at the University of Milan, Italy. She has a PhD in cellular and molecular biology from the University of Milan.

ANDREA SCALONI, PHD, is First Investigator at the Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council in Naples, Italy. He received his PhD in chemical sciences from the University of Rome "La Sapienza" in Italy.

D. ALLAN BUTTERFIELD, PHD, is Alumni Professor of Chemistry and Director of the University of Kentucky Center of Membrane Sciences in Lexington, Kentucky, USA. He received his PhD in physical chemistry from Duke University.

Read More Show Less

Table of Contents

1. Oxidatively Modified Proteins and Proteomic Technologies.

1.1 Chemical Modification of Proteins by Reactive Oxygen Species (E. Stadtman & R. Levine).

1.2 The Chemistry of Protein Modifications Elicited By Nitric Oxide and Related Nitrogen Oxides (D. Thomas, et al.).

1.3  Mass Spectrometry Approaches for the Molecular Characterization of Oxidatively/Nitrosatively Modified Proteins (A. Scaloni).

1.4 Thiol-disulfide Oxidoreduction of Protein Cysteines: Old Methods Revisted for Proteomics (V. Bonetto & P. Ghezzi).

1.5 Carbonylated Proteins and their Implication in Physiology and Pathology (R. Levine & E. Stadtman).

1.6 S-Nitrosation of Cysteine thiols as a Redox Signal (Y. Zhang & N. Hogg).

1.7 Detection of Glycated and GlycoOxidated Proteins (A. Lapolla, et al.).

1.8 MudPIT (Multidimensaional Protein Identification Technology) for Identification of Post-translational Protein Modifications in Complex Biological Mixtures (S. Thomas, et al.).

1.9 Use of a Proteomic Technique to Identify Oxidant-Sensitive Thiol Proteins in Cultured Cells (M. Hampton, et al.).

1.10 ICAT (Isotope-Code Affinity Tag) Approach to Redox Proteomics: Identification and Quantification of Oxidant-Sensitive Protein Thiols (M. Sethuraman, et al.).

1.11 Quantitative Determination of Free and Protein-Associated 3-nitrotyrosine and S-nitrosothiols in the Circulation by Mass Spectrometry and Other Methodologies: A Critical Review and Discussion from the Analytical and Review Point of View (D. Tsikas). 

2. Cellular Aspects of Protein Oxidation.

2.1 The Covalent Advantage: A New Paradigm for Cell Signaling Mediated by Thiol Reactive Lipid Oxidation Products (D. Dickinson, et al.).

2.2 Early Molecular Events During Response to Oxidative Stress in Human Cells by Differential Proteomics (G. Tell).

2.3 Oxidative Damage to Proteins: Structural Modifications and Consequences in Cell Function (E. Cabiscol & J. Ros).

2.4 Oxidative Damage and Cellular Senescence: Lessons from Bacteria and Yeast (T. Nyström).

3. Redox Proteomic Analysis in Human Diseases.

3.1 Proteins as Sensitive Biomarkers of Human Conditions Associated with Oxidative Stress (I. Dalle-Donne, et al.).

3.2 Degradation and Accumulation of Oxidized Proteins in Age-Related Diseases (P. Voss & T. Grune).

3.3 Redox Proteomics: A New Approach to Investgate Oxidative Stress in Alzheimer's Diseases (D. Butterfield, et al.).

3.4 Oxidized Proteins in Cardiac Ischemia-Reperfusion (J. Brennan & P. Eaton).

3.5 Proteome Anaylsis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients (T. Niwa).

3.6 Glyco-Oxidative Biochemistry in Diabetic Renal Injury (T. Miyata).

3.7 Quantitative Screnning of Protein Glycation, Oxidation, and Nitration Adducts by LC-MS/MS: Protein Damage in Diabetes, Uremia, Cirrhosis, and Alzheimer's Disease (P. Thornalley).

3.8 Protein Targets and Functional Consequences of Tyrosine Nitration in Vascular Disease (L. Baker, et al.).

3.9 Oxidation of Artery Wall Proteins by Myeloperoxidase: A proteomics Approach (T. Vaisar & J. Heinecke).

3.10 Oxidative Stress and Protein Oxidation in Pre-Eclampsia (M. Raijmakers, et al.).

3.11 The Involvement of Oxidants in the Etiology of Chronic Airway Diseases: Proteomic Approaches to Identify Redox Processes in Epithelial Cell Signal and Inflammation (A. van der Vliet, et al.).

3.12 Sequestering Agents of Intermediate Reactive Aldehydes as Inhibitors of Advanced Lipoxidation End-Products (ALEs) (M. Carini, et al.).

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)