Regulatory Peptides and Cognate Receptors

by Dietmar Richter (Editor)

Overview

In the last two decades, our knowledge on regulatory peptides and their cognate receptors, most of which are members of the seven transmembrane receptor families, has increased enormously. Regulatory peptides are small proteins which, besides their hormonal functions in regulating cellular metabolism in various tissues, may also act as neurotransmitters, and thus they often carry the prefix "neuro". Many of the cognate receptors involved in transducing the peptidergic signal across the cell membrane via a familiy of G proteins exist in multiple forms, the number of which frequently exceeds that of the corresponding peptide ligands. In this book, various peptide-receptor systems are discussed, e.g CRF, somatostatin, TRH, opioid peptides, vasopressin, and oxyin. It also discusses new strategies such as "reverse physiology" to uncover new peptides and orphan receptors.

Product Details

ISBN-13:	9783540653257
Publisher:	Springer Berlin Heidelberg
Publication date:	07/30/1999
Series:	Results and Problems in Cell Differentiation , #26
Edition description:	1999
Pages:	366
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?.- Thyrotropin Releasing Hormone (TRH), the TRH-Receptor and the TRH-Degrading Ectoenzyme; Three Elements of a Peptidergic Signalling System.- Corticotropin-Releasing Factor (CRF) and its Role in the Central Nervous System.- CRF and CRF Receptors.- Neural Oxyinergic Systems as Genomic Targets for Hormones and as Modulators of Hormone-Dependent Behaviors.- Vasopressin Receptors: Structural Functional Relationships and Role in Neural and Endocrine Regulation.- The Oxyin Receptor.- Targeted Mutagenesis of the Murine Opioid System.- Orphan Receptors and the Concept of Reverse Physiology: Discovery of the Novel Neuropeptide Orphanin FQ/Nociceptin.- Molecular Biology of the Receptors for Somatostatin and Cortistatin.- Novel Neurotransmitters for Sleep and Energy Homeostasis.- Galanin and Galanin Receptors.- The Cholecystokinin — Gastrin Family of Peptides and Their Receptors.- Function of the Neuropeptide Head Activator for Early Neural and Neuroendocrine Development.- Invertebrate Neurohormones and Their Receptors.

Editorial Reviews

This is Volume 26 in a series entitled Results and Problems in Cell Differentiation. Recent work in the field of bioactive peptides has led to a major increase in both identification and understanding, and this provides the impetus for this book. The audience is anyone working with either peptides or their receptors. A short introductory chapter on the evolutionary puzzle of initial origin (peptide or receptor) is followed by brief reviews of most of the pituitary peptides, and several of their receptors. Neurotransmitter peptides, galanin, cholecystokinin, and orphan receptors are covered in subsequent chapters. Authorship of each section is by experienced investigators and the overall quality of coverage is high. Each chapter is accompanied by a useful bibliography. The focus of this book is limited to peptides of mammalian origin, which limits discussions of evolution and function in lower animals. Nevertheless, this volume will be of interest to scientists active in the field.

Eugene A. Davidson