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Regulatory T Cells in the Control of Host-Microorganism Interactions
     

Regulatory T Cells in the Control of Host-Microorganism Interactions

by Yasmine Belkaid
 
Each microenvironment requires a specific set of regulatory elements that are finely and constantly tuned to maintain local homeostasis. Various populations of regulatory T cells contribute to the maintenance of this equilibrium and establishment of controlled immune responses. In particular, regulatory T cells limit the magnitude of effector responses, which may

Overview

Each microenvironment requires a specific set of regulatory elements that are finely and constantly tuned to maintain local homeostasis. Various populations of regulatory T cells contribute to the maintenance of this equilibrium and establishment of controlled immune responses. In particular, regulatory T cells limit the magnitude of effector responses, which may result in failure to adequately control infection. However, regulatory T cells also help limit collateral tissue damage caused by vigorous antimicrobial immune responses against pathogenic microbes as well as commensals. In this review, we describe various situations in which the balance between regulatory T cells and effector immune functions influence the outcome of host-microorganism coexistence and discuss current hypotheses and points of polemic associated with the origin, target, and antigen specificity of both endogenous and induced regulatory T cells during these interactions.

Product Details

BN ID:
2940013207547
Publisher:
Annual Reviews
Publication date:
10/24/2011
Series:
Annual Review of Immunology , #27
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
38
File size:
6 MB

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