Replaceable You: Adventures in Human Anatomy

by Mary Roach

Overview

One of Lit Hub’s Most Anticipated Books of 2025

From the New York Times best-selling author of Stiff and Fuzz, a rollicking exploration of the quest to re-create the impossible complexities of human anatomy.

The body is the most complex machine in the world, and the only one for which you cannot get a replacement part from the manufacturer. For centuries, medicine has reached for what’s available—sculpting noses from brass, borrowing skin from frogs and hearts from pigs, crafting eye parts from jet canopies and breasts from petroleum by-products. Today we’re attempting to grow body parts from scratch using stem cells and 3D printers. How are we doing? Are we there yet?

In Replaceable You, Mary Roach explores the remarkable advances and difficult questions prompted by the human body’s failings. When and how does a person decide they’d be better off with a prosthetic than their existing limb? Can a donated heart be made to beat forever? Can an intestine provide a workable substitute for a vagina?

Roach dives in with her characteristic verve and infectious wit. Her travels take her to the OR at a legendary burn unit in Boston, a “superclean” xeno-pigsty in China, and a stem cell “hair nursery” in the San Diego tech hub. She talks with researchers and surgeons, amputees and ostomates, printers of kidneys and designers of wearable organs. She spends time in a working iron lung from the 1950s, stays up all night with recovery techs as they disassemble and reassemble a tissue donor, and travels across Mongolia with the cataract surgeons of Orbis International.

Irrepressible and accessible, Replaceable You immerses readers in the wondrous, improbable, and surreal quest to build a new you.

Product Details

ISBN-13:	9781324050636
Publisher:	Norton, W. W. & Company, Inc.
Publication date:	09/16/2025
Sold by:	Barnes & Noble
Format:	eBook
Pages:	288

About the Author

Mary Roach is the author of seven best-selling works of nonfiction, including Grunt, Stiff, and, most recently, Fuzz. Her writing has appeared in National Geographic and the New York Times Magazine, among other publications. She lives in California.

Hometown:

San Francisco, California

Place of Birth:

New Hampshire

Education:

B.A., Wesleyan University, 1981

Website:

http://www.maryroach.net/

Editorial Reviews

"Mary Roach has had a more direct impact on my career than any other writer. She is her own genre of book—gonzo, hilarious, wildly educational. This is Roach at her finest."

Daniel Kraus

"In her brilliant (and brilliantly funny book) Replaceable You, Mary Roach explores the puzzle of the human body, the way we can assemble and reassemble the very human pieces into different versions of who we are and how we work. The result is intriguing, compassionate, wise and—as with all her books—addictively readable. Or to put this another way: Don't miss it."

Deborah Blum

"We are all replaceable to some degree or another . . . with the exception of Mary Roach. There is no one and nothing like her—singular, bizarre, dedicated, passionate, fascinating. Her writing traffics at the unusual intersection of science, storytelling, and humor. That is a very tricky intersection to navigate, and no one does it as masterfully or consistently as she. I devour everything she writes."

Jason Alexander