Respiratory Genetics
  • Alternative view 1 of Respiratory Genetics
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Respiratory Genetics

by Edwin Silverman, Scott Weiss, Steven Shapiro, David Lomas
     
 

ISBN-10: 0340814322

ISBN-13: 9780340814321

Pub. Date: 09/30/2005

Publisher: Taylor & Francis

This authoritative reference brings together current knowledge in the field of respiratory genetics in a single volume for the first time. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection and storage, bioinformatics, and

Overview

This authoritative reference brings together current knowledge in the field of respiratory genetics in a single volume for the first time. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection and storage, bioinformatics, and molecular genetics. This is followed by a series of disease-specific chapters which review epidemiology; natural history; monogenic components and complex traits where relevant; disease management, including genetic counseling issues; and likely future developments. Chapters are written in a uniform structure—ensuring consistency of approach throughout—and each concludes with a summary highlighting practical "take-home" messages regarding patient management for the reader. It is also highly illustrated, including color plates where appropriate.

Product Details

ISBN-13:
9780340814321
Publisher:
Taylor & Francis
Publication date:
09/30/2005
Series:
A Hodder Arnold Publication Series
Pages:
496
Product dimensions:
10.90(w) x 8.30(h) x 1.30(d)

Table of Contents

Part 1: Key Concepts in Respiratory Genetics
Overview of human genetics
Phenotypes for Human Respiratory Genetics
Testing for association in genetic studies
Sample Collection and Genotyping for Human Respiratory Genetics
Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics
Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing
Bioinformatics: public databases and SNPs
Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues
Functional genomics: clinical functional genomics
Functional genomics: expression and purification of recombinant proteins
Functional genomics: functional characterization of a protein
Functional genomics: biophysical analysis of proteins and protein–protein interactions
Functional genomics: crystallography, nuclear magnetic resonance, and modeling
Functional genomics: functional analysis of mutant proteins in cells
Genomic physiology in animals
Pharmacogenetics
Part 2: Obstructive lung diseases
Asthma genetics
Chronic obstructive pulmonary disease
Cystic fibrosis
Part 3: Interstitial lung diseases
Idiopathic pulmonary fibrosis
Sarcoidosis
Part 4: Miscellaneous pulmonary conditions
Pulmonary hypertension
Genetics of lung cancer
Respiratory infections
Congenital, metabolic, and neuromuscular diseases
Other rare lung diseases: disorders of surfactant homeostasis
Other rare lung diseases: lymphangioleiomyomatosis
Other rare lung diseases: Hermansky–Pudlak Syndrome

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