Retroviruses and Insights into Cancer / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$173.31
Used and New from Other Sellers
Used and New from Other Sellers
from $166.21
Usually ships in 1-2 business days
(Save 24%)
Other sellers (Hardcover)
  • All (6) from $166.21   
  • New (4) from $166.21   
  • Used (2) from $173.30   

Overview

Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Read More Show Less

Product Details

  • ISBN-13: 9780387095806
  • Publisher: Springer New York
  • Publication date: 10/28/2010
  • Series: Language and Communication Series , #1
  • Edition description: 2011
  • Edition number: 1
  • Pages: 363
  • Product dimensions: 0.88 (w) x 9.21 (h) x 6.14 (d)

Table of Contents

1 Overview of Retrovirology Naomi Rosenberg 1

2 Mechanisms of Oncogenesis by Retroviruses Karen L. Beemon Mohan Bolisetty 31

3 Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses Sandra K. Ruscetti Joan L. Cmarik 53

4 Genetics of Host Resistance to Retroviruses and Cancer Chioma M. Okeoma Susan R. Ross 95

5 Endogenous Retroviruses and Cancer Jaquelin P. Dudley Jennifer A. Mertz Sanchita Bhadra Massimo Palmarini Christine A. Kozak 119

6 Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer Matthew Kesic Patrick L. Green 163

7 Cancers Induced by Piscine Retroviruses Sandra L. Quackenbush James W. Casey Paul R. Bowser Joel Rovnak 191

8 The Immune Response to Oncogenic Retroviruses Melanie R. Rutkowski William R. Green 219

9 Retrovirus-induced Immunodeficiency and Cancer Laura S. Levy 259

10 Retroviruses as Tools to Identify Oncogenes and Tumor Suppressor Genes James C. Neil Monica A. Stewart 285

11 Emerging Retroviruses and Cancer Maribeth V. Eiden Dwayne L. Taliaferro 307

Index 335

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)