Rheumatoid Arthritis / Edition 1

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This monograph correlates basic observations of rheumatoid arthritis with clinical aspects of the disease process and current treatment therapies. Covers the history of rheumatoid arthritis, demography and epidemiology, initiating and sustaining factors, immunogenetics, initiations of the immune response in synovium, rheumatoid factors and autoimmunity, autocrine and paracrine control of rheumatoid inflammation, acute inflammation and synovial fluid, synovial cells and their transformation, the dynamics of joint destruction, articular and extra-articular manifestations, clinical and radiographic diagnosis, and prognosis.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780721652498
  • Publisher: Elsevier Health Sciences
  • Publication date: 1/28/1997
  • Edition number: 1
  • Pages: 433

Table of Contents

1 Joints and Connective Tissue: The Targets of Rheumatoid Arthritis 3
2 History and Epidemiology of Rheumatoid Arthritis: How Long Has It Affected Us, and Who Is at Risk? 21
3 Immunogenetics 28
4 Is There One Cause of Rheumatoid Arthritis? 41
5 T Lymphocytes 52
6 B Lymphocytes and Rheumatoid Factor 74
7 Leukocyte Translocation from Blood to Synovium 89
8 Cytokines, Lymphokines, Growth Factors, and Chemokines 105
9 Rheumatoid Synovium: Complex, and More Than the Sum of its Parts 126
10 Cartilage and the Mechanisms for its Destruction 150
11 The Pannus-Cartilage Junction: Focus of the Destructive Process 158
12 Enzymes Responsible for Joint Destruction 168
13 Intra-articular Pressure, Blood Flow, and pH in the Rheumatoid Joint 179
14 Synovial Fluid: A Sink for Neutrophils and Inflammatory Mediators 183
15 Nitric Oxide: Messenger for Modulation of Inflammation 195
16 The Pain of Arthritis - Neuroendocrine Associations 198
17 Phospholipase A[subscript 2], Cyclo-oxygenase, Prostaglandins, and Leukotrienes 202
18 Immune Complexes, Complement, Kinins, Clot Formation, and Fibrinolysis 206
19 Clinical Features and Differential Diagnosis 215
20 Course and Complications of Established Rheumatoid Arthritis 232
21 Diagnostic Imaging in Rheumatoid Arthritis 259
22 Laboratory Assays: The Acute-Phase Response 271
23 Biochemical Markers Associated with Rheumatoid Arthritis 273
24 Assessment of Rheumatoid Arthritis 279
25 Prognosis for Patients with Rheumatoid Arthritis 305
26 General Principles of Therapy 317
27 Use of Patient Education and Physical Modalities in Early Treatment 324
28 Diet and Rheumatoid Arthritis 332
29 Nonsteroidal Anti-Inflammatory Drugs, Including Aspirin 337
30 The Role of Glucocorticoids 350
31 Second-Line Treatment 364
32 Methotrexate 379
33 Cytotoxic, Immunosuppressive, and Biologic Therapy 390
34 Combination Therapy 412
35 Antibiotics and Other Novel Therapies 415
Appendix Cited Abstracts of the 1995 ACR National Scientific Meeting 418
Index 421
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