Rheumatoid Arthritis / Edition 1

Rheumatoid Arthritis / Edition 1

by Edward D. Harris
     
 

This monograph correlates basic observations of rheumatoid arthritis with clinical aspects of the disease process and current treatment therapies. Covers the history of rheumatoid arthritis, demography and epidemiology, initiating and sustaining factors, immunogenetics, initiations of the immune response in synovium, rheumatoid factors and autoimmunity, autocrine

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Overview

This monograph correlates basic observations of rheumatoid arthritis with clinical aspects of the disease process and current treatment therapies. Covers the history of rheumatoid arthritis, demography and epidemiology, initiating and sustaining factors, immunogenetics, initiations of the immune response in synovium, rheumatoid factors and autoimmunity, autocrine and paracrine control of rheumatoid inflammation, acute inflammation and synovial fluid, synovial cells and their transformation, the dynamics of joint destruction, articular and extra-articular manifestations, clinical and radiographic diagnosis, and prognosis.

Product Details

ISBN-13:
9780721652498
Publisher:
Elsevier Health Sciences
Publication date:
01/28/1997
Pages:
433
Product dimensions:
7.25(w) x 10.25(h) x (d)

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Meet the Author

Table of Contents

1Joints and Connective Tissue: The Targets of Rheumatoid Arthritis3
2History and Epidemiology of Rheumatoid Arthritis: How Long Has It Affected Us, and Who Is at Risk?21
3Immunogenetics28
4Is There One Cause of Rheumatoid Arthritis?41
5T Lymphocytes52
6B Lymphocytes and Rheumatoid Factor74
7Leukocyte Translocation from Blood to Synovium89
8Cytokines, Lymphokines, Growth Factors, and Chemokines105
9Rheumatoid Synovium: Complex, and More Than the Sum of its Parts126
10Cartilage and the Mechanisms for its Destruction150
11The Pannus-Cartilage Junction: Focus of the Destructive Process158
12Enzymes Responsible for Joint Destruction168
13Intra-articular Pressure, Blood Flow, and pH in the Rheumatoid Joint179
14Synovial Fluid: A Sink for Neutrophils and Inflammatory Mediators183
15Nitric Oxide: Messenger for Modulation of Inflammation195
16The Pain of Arthritis - Neuroendocrine Associations198
17Phospholipase A[subscript 2], Cyclo-oxygenase, Prostaglandins, and Leukotrienes202
18Immune Complexes, Complement, Kinins, Clot Formation, and Fibrinolysis206
19Clinical Features and Differential Diagnosis215
20Course and Complications of Established Rheumatoid Arthritis232
21Diagnostic Imaging in Rheumatoid Arthritis259
22Laboratory Assays: The Acute-Phase Response271
23Biochemical Markers Associated with Rheumatoid Arthritis273
24Assessment of Rheumatoid Arthritis279
25Prognosis for Patients with Rheumatoid Arthritis305
26General Principles of Therapy317
27Use of Patient Education and Physical Modalities in Early Treatment324
28Diet and Rheumatoid Arthritis332
29Nonsteroidal Anti-Inflammatory Drugs, Including Aspirin337
30The Role of Glucocorticoids350
31Second-Line Treatment364
32Methotrexate379
33Cytotoxic, Immunosuppressive, and Biologic Therapy390
34Combination Therapy412
35Antibiotics and Other Novel Therapies415
AppendixCited Abstracts of the 1995 ACR National Scientific Meeting418
Index421

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