Rho GTPases / Edition 1

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More About This Textbook


Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility. Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.

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Product Details

  • ISBN-13: 9780306479922
  • Publisher: Springer US
  • Publication date: 5/28/2004
  • Series: Molecular Biology Intelligence Unit Series
  • Edition description: 2004
  • Edition number: 1
  • Pages: 248
  • Product dimensions: 6.22 (w) x 9.32 (h) x 0.84 (d)

Table of Contents

1 Signalling networks of Rho GTPases 1
2 Intracellular targeting of Rho family GTPases : implications of localization on function 17
3 Regulation of the RhoGTPases by RhoGDI 32
4 Rho family guanine nucleotide exchange factors 46
5 The superfamily of Rho GTPase-activating proteins 68
6 Rnd proteins : intriguing members of the Rho family 96
7 Rho GTPases in the organization of the actin cytoskeleton 107
8 Cell-cell adhesion 115
9 Ro GTPases and cell motility 141
10 The RhoGTPase in tumor invasion 155
11 Rho family GTPases and cellular transformation 163
12 Rho GTPases in lipid metabolism 185
13 The role of Rho GTPases in vesicle trafficking 196
14 The dictyostelium Rho family of proteins and effectors 208
15 Rho GTPases in plants 219
Index 231
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