Rho GTPases / Edition 1

Rho GTPases / Edition 1

by Marc H. Symons
     
 

ISBN-10: 0306479923

ISBN-13: 9780306479922

Pub. Date: 05/28/2004

Publisher: Springer US

Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the…  See more details below

Overview

Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins.
This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility.
Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.

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Product Details

ISBN-13:
9780306479922
Publisher:
Springer US
Publication date:
05/28/2004
Series:
Molecular Biology Intelligence Unit Series
Edition description:
2004
Pages:
248
Product dimensions:
6.22(w) x 9.32(h) x 0.84(d)

Table of Contents

Preface
1Signalling networks of Rho GTPases1
2Intracellular targeting of Rho family GTPases : implications of localization on function17
3Regulation of the RhoGTPases by RhoGDI32
4Rho family guanine nucleotide exchange factors46
5The superfamily of Rho GTPase-activating proteins68
6Rnd proteins : intriguing members of the Rho family96
7Rho GTPases in the organization of the actin cytoskeleton107
8Cell-cell adhesion115
9Ro GTPases and cell motility141
10The RhoGTPase in tumor invasion155
11Rho family GTPases and cellular transformation163
12Rho GTPases in lipid metabolism185
13The role of Rho GTPases in vesicle trafficking196
14The dictyostelium Rho family of proteins and effectors208
15Rho GTPases in plants219
Index231

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