Risk Assessment and Management in Cancer Genetics

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The need to expand expertise in cancer genetics beyond highly specialized genetics clinics is increasingly being recognized. In response, this practical book provides oncologists, specialist nurses, genetic counsellors, family doctors, and geneticists with comprehensive and easy-to-use guidelines on risk assessment and appropriate management.

The book focuses on common familial cancers such as breast, colorectal, ovary, prostate and melanoma, and separate chapters cover cancer predisposing syndromes such as neurofibromatosis, familial adenomatous polyposis and their management.

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Editorial Reviews

Doody's Review Service
Reviewer: Stephanie A. Cohen, MS (St. Vincent Hospital and Health Care Center)
Description: This book provides detailed information about common familial cancers as well as less well-known hereditary cancer syndromes. For each hereditary cancer type, the authors discuss risk assessment, genetic testing guidelines, and management recommendations for affected and at-risk individuals.
Purpose: Though there is no formal preface stating the editors' objectives, the book jacket states that they seek to make the typically highly specialized information on hereditary cancer syndromes accessible to a wider audience. Many providers, even specialists in oncology and genetics, shy away from the topic of hereditary cancer syndromes due to the complex nature of the information. This book is a very practical guide to hereditary cancer syndromes and achieves the goal of condensing the information into a useful format.
Audience: The book jacket states that it is written for specialists such as oncologists, nurses, genetic counselors, geneticists, and family doctors who do not currently provide specific cancer genetic services but presumably would have the background knowledge to do so. It is very useful for anyone in the position to provide genetic counseling and testing for hereditary cancers, regardless of their experience in the very specialized field of cancer genetics. The book does assume some basic genetics knowledge, which may be frustrating to some non-genetics specialists. The editors of the book and authors of the individual chapters may not be widely recognized by a North American audience, with the exception of the two chapters specifically addressing the North American experience that are written by two well-known and respected authors. Some of the authors are widely published in the area in which they wrote. However, it appears that a few chapters, though clearly written by knowledgeable cancer genetic professionals, were not written by authors in their area of expertise, on the basis of published literature on that topic.
Features: This book covers a wide variety of topics, including basic information on taking a pedigree and making a referral to a more sophisticated discussion of risk assessment and management of hereditary cancers. There are several chapters covering the more common hereditary cancers such as breast and colon, as well as rare hereditary cancer syndromes and less common hereditary cancers. The discussion of hereditary cancers includes features and diagnoses of the syndrome, differential diagnoses, molecular genetics, clinical testing, and management. The risk assessment tables are presented in a very useable format for clinical practice. The chapters on less common familial cancers and tumor predisposing syndromes were particularly useful summaries with nice references. The information is disappointingly limited on some of the more recent advances in hereditary cancer syndromes, including MYH and AFAP. Finally, the book was written primarily by European specialists, though there is an attempt to reach out to the North American audience with two chapters specific to this experience.
Assessment: Despite a few minor shortcomings, this comprehensive overview is a very practical guide that will be useful for both experienced cancer genetics professionals and novices. It will be a good teaching guide for medical and genetic counseling students who wish to gain more knowledge in the area of hereditary cancers. The compact and practical nature will make it a good addition to the bookshelf of specialists who wish to have a handy reference on cancer genetics.
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Product Details

  • ISBN-13: 9780198529606
  • Publisher: Oxford University Press, USA
  • Publication date: 11/1/2005
  • Pages: 288
  • Product dimensions: 9.20 (w) x 6.60 (h) x 0.70 (d)

Meet the Author

Professor D. Gareth Evans is secretary of the UK Cancer Genetics Group. He was chairman of the UK National Institute of Clinical Excellence guidelines on familial breast cancer, Chairman of the International Collaborative Group on Familial Breast and Ovarian Cancer and on the Editorial Board of Familial Cancer.
Professor Jan Friedman is editor of the journal Genetics in Medicine.

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Table of Contents

1 How to evaluate a family history 3
2 Guidelines for referral in Europe 13
3 Guidelines for genetic counselling, testing and referral in North America 23
4 Principles and applications of gene testing for common cancers 31
5 Risk estimation in breast cancer 47
6 Risk estimation in colorectal cancer 65
7 Risk estimation in ovarian cancer 73
8a Management of familial breast and breast-ovarian cancer in Europe 83
8b Management of familial breast and ovarian cancer in North America 95
9 Management of familial adenomatous polyposis and other inherited polyposis syndromes 103
10 Management of hereditary non-polyposis colorectal cancer 123
11 Management and risk assessment of less common familial cancers 139
12 The neurofibromatoses 169
13 von Hippel-Lindau disease 197
14 Multiple endocrine neoplasias 207
15 Gorlin syndrome 215
16 Li-Fraumeni syndrome 227
17 Other tumour predisposing syndromes 237
18 The ethical and insurance issues of cancer genetics 247
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