Risk Assessment of Phytochemicals in Food: Novel Approaches / Edition 1

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Overview

Providing the scientific background on the risk and safetyassessment of toxicity in phytochemicals in everyday food, thismonograph contains the pros and cons of 20 testing methods, withcomments by the internationally acknowledged and independent DFGSenate Commission on Food Safety.
Supplemented by 40 poster contributions on phytochemicals and theireffects.

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Product Details

  • ISBN-13: 9783527329298
  • Publisher: Wiley
  • Publication date: 2/8/2011
  • Series: Forschungsberichte (DFG) Series
  • Edition number: 1
  • Pages: 476
  • Product dimensions: 6.70 (w) x 9.40 (h) x 0.90 (d)

Table of Contents

Vorwort.

Preface.

1. Bericht und Schlussfolgerungen.

1.1 Einleitung.

1.2 Methodenübergreifende Aspekte.

1.3 Methoden.

1.4 Schlussfolgerungen und Empfehlungen.

1.5 Fazit.

2. Report and Conclusions.

2.1 Preface.

2.2 Transdisciplinary Aspects.

2.3 Methodologies.

2.4 Conclusions and Recommendations.

2.5 Concluding Remarks.

3. Contributions.

3.1 Visions on Toxicity Testing in the 21st Century:Reflections on a Strategy Document of the US National ResearchCouncil (Marcel Leist, Thomas Hartung, and Pierluigi Nicotera).

3.2 Safety Assessment of Botanicals and Botanical PreparationsUsed as Ingredients in Food Supplements: Testing an European FoodSafety Authority-Tiered Approach (Gerrit Speijers, Bernard Botex,Birgit Dusemund et al.).

3.3 In Silico Toxicology Screening of the Rodent CarcinogenicPotential of Phytochemicals Using Quantitative Structure-ActivityRelationship Analysis (Luis G. Valerio Jr., Naomi L. Kruhlak, andR. Daniel Benz).

3.4 Testing Computational Toxicology Models with Phytochemicals(Luis G. Valerio, Jr., Kirk B. Arvidson, Emily Busta et al.).

3.5 In Silico Models to Establish Level of Safety Concern inAbsence of Sufficient Toxicological Data (Benoît Schilter,Manuel Dominguez Estevez, Myriam Coulet et al.).

3.6 In Silico Methods for Physiologically Based Biokinetic(PBBK) Models Describing Bioactivation and Detoxification ofCoumarin and Estragole: Implications for Risk Assessment (Ivonne M.C. M. Rietjens, Ans Punt, Benoît Schilter et al.).

3.7 In Vitro Models for Carcinogenicity Testing – Realityor Fantasy? (Pablo Steinberg, Carsten Müller, Kristina Ullmannet al.).

3.8 Carcinogen Specific Expression Profiling: Prediction ofCarcinogenic Potential? (Hans-Jürgen Ahr, and HeidrunEllinger-Ziegelbauer).

3.9 Safety and Biological Efficacy Testing of Phytochemicals: AnIndustry Approach (Anette Thiel, Jochen Bausch, Mareike Beck etal.).

3.10 Metabolite Profiling in Rat Plasma as a Potential New Toolfor the Assessment of Chemically Induced Toxicity (Hennicke Kamp,Roland Buesen, Eric Fabian et al.).

3.11 Profiling Techniques in Nutrition and Food Research(Hannelore Daniel).

3.12 The Complex Links between Dietary Phytochemicals and HumanHealth Deciphered by Metabolomics (Claudine Manach, Jane Hubert,Rafael Llorach et al.).

3.13 Anti-Oxidative and Antigenotoxic Properties of Vegetablesand Dietary Phytochemicals: The Value of Genomics Biomarkers inMolecular Epidemiology (Theo M. C. M. de Kok, Pim de Waard, LonnekeC. Wilms et al.).

3.14 The Japanese Toxicogenomics Project: Application ofToxicogenomics – Utilizing Toxicogenomics into Drug SafetyScreening (Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama etal.).

3.15 Toxicology and Risk Assessment of Coumarin : Focus on HumanData (Klaus Abraham, Friederike Wöhrlin, Oliver Lindtner etal,).

3.16 Risk from Furocounmarins in Food? An Exposure Assessment(Dieter Schrenk, Sabine Guth, Nicole Raquet et al.).

3.17 Transcriptome Analysis in Benefit-Risk Assessment ofMicronutrients and Bioactive Food Components (Jaap Keijer, YvonneG. J. van Helden, Annelies Bunschoten et al.).

3.18 Colerectal and Prostate Cancer: The Role of Candidate Genesin Nutritional Pathways (Ulrike Peters).

3.19 Glucosinolates: DNA Adduct Formation In Vivo andMutagenicity In Vitro (Chimgee Baasanjav Gerber, Wolfram Engst,Simone Florian et al.).

3.20 Defence Mechanisms against Toxic Phytochemicals in the Dietof Domestic Animals (Johanna Fink-Gremmels).

4. Posters.

4.1 Coumarin Risk Assessment: Lesson from Human Data (KlausAbraham, Klaus-Erich Appel, and Alfonso Lampen).

4.2 Coffee and Coffee Compounds are Effective Antioxidants inHuman Cells and In Vivo (Tamara Bakuradz, Matthias Baum, GerhardEisenbrand et al.).

4.3 Studying Absorption, Distribution, Metabolism, and Excretionof a Complex Extract (Mareike Beck, Martine Bruchlen, Volker Elsteet al.).

4.4 Polyphenolic Apple Extracts and their Constituents ModulateDNA Strand Breaks and Oxidation Damage in Human Colon CarcinomaCells (Phillip Bellion, Frank Will, Helmut Dietrich el al.).

4.5 Comparative Evaluation of Experimental Data onα-Amylase Inhibition by Flavonoids Using Molecular Modelling(Lisa M. Bode, Thomas Homann, Harshadrai M. Rawel et al.).

4.6 Potential Risk of Furan in Foods (J. Brück, DieterSchrenk, U. Schauer et al.).

4.7 Comparative Study on the Toxicity of Alternariol andAlternariol Monomethyl Ether in Human Tumour Cells of DifferentOrigin (Julia Burkart, Markus Fehr, Gudrun Pahlke et al.).

4.8 A Role for Resvernatrol and Curcumine in Sensitization ofGlioblastoma Cells to Genotoxic   Stress Induced by AlkylatingChemotherapeutics (Markus Christmann, N. Berdelle, G. Nagel etal.).

4.9 BfR Risk Assessment of Alkaloids as Ingredients andContaminants of Food: Quinine, Opium Alkaloids, and SenecioPyrrolizidine Alkaloids (Birgit Dusemund, Kalus-Erich Appel, andAlfonso Lampen).

4.10 Elucidation of the Genotoxic Activity of the AlkaloidEllipticine in Human Cell Lines (Eva Frei, Jitka Poljaková,Lucie Bořek-Dohalská et al.).

4.11 Dietary Supplements and Herbal Medicinal Products –for a Clear Differentiation. Statement of the Society forPhytotherapy (FPT) to the “Article 13 Health ClaimList” of the EFSA (Frauke Gaedcke, Bernd Eberwein, OlafKelber et al.).

4.12 Assessment of Genotoxicity of Herbal Medicinal PreparationsAccording to the Guidelines EMEA/HMPC/107079/2007 – A ModelProject of Kooperation Phytopharmaka, Bonn, Germany (FraukeGaedcke. Olaf Kelber, Karin Kraft et al.).

4.13 Implications for an Adverse Effect f Vitamin C inPhotodynamic Therapy (Stefanie Grimm, Nicolle Breusing, and TilmanGrune).

4.14 Using the Nematode Caenorhabditis elegans to Identify Modeof Action of the Flavonoid Myricetin (Gregor Grünz, B.Spanier, and Hannelore Daniel).

4.15 Low-Temperature Plasma – Mild Preservation Technologyfor Minimal Processed Fresh Food? (Franziska Grzegorzewski, O.Schlüter, J. Ehlbeck et al.).

4.16 Influence of Fumonisin B 1 on Gene Expression and CytokineProduction (Dorothee C. Hecker, Christian Salzig, and DieterSchrenk).

4.17 Effects of Quercetin on the Detoxification of the FoodContaminant Benzo[a]pyrene in the Human Intestinal Caco-2 CellModel (Stefanie Hessel, Andreas John, Albrecht Seidel et al.).

4.18 Risk Assessment of T-2 and HT-2 Toxin Using Human Cells inPrimary Culture (Dennis Mulac, Miaka Königs, Gerald Schwerdtet al.).

4.19 Pyrrolizidine Alkaloids in Honey Bee Products (MichaelKempf, Till Beuerle, Annika Reinhard et al.).

4.20 Identification of Molecular Determinants for Cytotoxicityof Isoloquiritigenin from Liquorice (Glycyrrhiza glabra) towardsLeukemia Cell Lines (V. Badireenath Konkimalla, Anne Kramer, YujieFu et al.).

4.21 Functional Effects of Polyphenol Metabolites Produced byColonic Microbiota in Colon Cells In Vitro (Claudia Miene andMichael Glei).

4.22 Lifelong Exposure to Isoflavones Results in a ReducedResponsivity of the Mammary Gland in Female Rats towards Oestradiol(Almut Milzberger, Torsten Hertrampf, Frank Möller etal.).

4.23 Derivation of Maximum Amounts for the Addition ofFunctional Ingredients to Foods (Sina Tischer, Oliver Lindter ,Almut Bauch et al.).

4. 24 Constituents of Ginger Induce Micronuclei in Two MammalianCell Systems In Vitro (Erika Pfieffer, Julia S. Dempe, Marina J.Gary et al.).

4.25 Relative Photomutagenic Potency of Furocoumarins andLimettin (Christiane Lohr, Dieter Schrenk, and Nicole Raquet).

4.26 Degradation of Green Tea Catechins (Markus Schantz, ThomadErk, and Elke Richling).

4.27 Evaluation of the Cytotoxic Effects of Herbal HomeopathicExtracts in Primary Human Hepatocytes In Vitro (Ulrike Sobeck, B.Rüdinger, F. Stintzing et al.).

4.28 Modulation of Antioxidant Gene Expression by Apple Juice inRats (Bülent Soyalan, J. Minn, Hans-Joachim Schmitz etal.).

4.29 Predictivity Comparison between Screening Assays forBacterial Mutagenicity for Natural Compounds: Micro-Ames vs. AmesFluctuation Method (Gerlinde Pappa, Tina Wöhrle, Anette Thielet al.).

4.30 Automated In Vitro Micronucleus Testing of NaturalCompounds in Correlation with Hydrogen Peroxide (Gerlinde Pappa,Tina Wöhrle, Anette Thiel et al.).

4.31 Permeability of Apple Polyphenols on Inflammatory GeneModel and their Influence on Tight Junctions (Hannah Bergmann,Dorothee Rogoll, Wolfgang Scheppach et al.).

4.32 Influence of Apple Polyphenols on Inflammatory GeneExpression (Sven Triebel, Ralph Melcher, Gerhard Erkel et al.).

4.33 Diethylstilbestrol-Like Effect of Genistein on GeneExpression of Wnt-Signalling Components in the Endometrial IshikawaCell Line (Jörg Wagner and Leane Lehmann).

4.34 Effect of Dietary Flavonoids in Different Cell Lines:Comparison of Uptake, Modulation of Oxidative Stress and CytotoxicEffects (Wim Wätjen, Sven Ruhl, Ricarda Rohrig et al.).

4.35 Risk-Benefit Considerations of Isoflavone Supplements inthe Treatment of Menopausal Vasomotor Symptoms (Uta Wegewitz, KlausRichter, A. Jacobs et al.).

4.36 Effect of Different Catechins on the Growth of HT-29 Cells(Stefanie Wiese, Tuba Esatbeyoglu, Peter Winterhalter et al.).

4.37 Determination of the Isoflavone Content of Soy-Based InfantFormula of the German Market Using a Box-Behnken ExperimentalDesign for Optimizing the Analytical Conditions (Stefanie Witte,Hans-Peter Kruse, and Sabine E. Kulling).

5. Appendix.

Participants of the Symposium Risk Assessment of Phytochemicalsin Food – Novel Approaches.

Members of the DFG Senate Commission on Food Safety: Mandate2007-2010. 

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