RNA Binding Proteins: New Concepts in Gene Regulation / Edition 1

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RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.
Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.

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Product Details

  • ISBN-13: 9780792376125
  • Publisher: Springer US
  • Publication date: 12/31/2001
  • Series: Endocrine Updates Series , #16
  • Edition description: 2002
  • Edition number: 1
  • Pages: 308
  • Product dimensions: 6.44 (w) x 9.56 (h) x 0.79 (d)

Table of Contents

Sect. I Translational Control
1 The role of RNA-binding proteins in IRES-dependent translation 1
2 Translational regulation of masked maternal mRNAs in early development 35
3 Poly-C binding proteins: Cellular regulators of mRNA fate and function 53
4 Autoregulation of protein synthesis by translation 71
5 Translational initiation of ornithine decarboxylase mRNA 87
Sect. II mRNA Metabolism
6 Regulation of mRNA stability by AUFI 101
7 RNA binding by members of the 70-kDa family of molecular chaperones 119
8 Post-transcriptional control of type-1 plasminogen activator inhibitor mRNA 135
9 Post-transcriptional control of the GAP-43 mRNA by the ELAV-like protein HuD 157
Sect. III Hormonal and Homeostatic Regulation
10 RNA-dependent protein kinases 175
11 Regulation of messenger RNA-binding proteins by protein kinases A and C 193
12 Post-transcriptional regulation of iron metabolism 213
13 Cytochrome P450 RNA-protein interactions 225
14 Site-specific cleavage of insulin-like growth factor II mRNAs 239
15 Hormonal regulation of the EGF/receptor system 255
16 The role of RNA binding proteins in tumorigenesis 271
17 Regulation of G-protein coupled receptor cytosolic mRNA binding proteins 285
Index 307
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