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In the 15 years since the last Institute of Laboratory Animal Resources report on the general management of rodents was published, important advances in biomedical research and increased public awareness have created a new environment for animal research. Modern technology-such as insertion of functional genes from other species into mice or rats, elimination of a single selected gene or function in mice, and the re-creation of elements of the human immune system in mice-has greatly expanded the usefulness of rodents in drug development and as models of human diseases. The technologic requirements of such advanced systems have led to improved understanding and implementation of environmental requirements for the care and use of rodents in research. The intent of this report is to provide current information to laboratory animal scientists (including both animal-care technicians and veterinarians), investigators, research technicians, and administrators on general elements of rodent care and use that should be considered both for optimal design and conduct of research and to meet current standards of care and use.

In the 15 years since the Institute of Laboratory Animal Resources issues its last report on general management of rodents, advances in biomedical technology and increased public awareness of laboratory animals issues have created a new research environment. This new volume brings researchers up to date on both of these aspects of laboratory investigation and provides a comprehensive resource manual for management of laboratory rodents. Index.

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Considers the establishment of devolved government in the traditionally hierarchical countries of Eastern Europe, looking at the experiences of countries including the Czech Republic, Estonia, Hungary, and Moldova. Examines how resources could be redistributed across regions, efforts to strike a balance between tendencies to over-centralize and tendencies towards fragmentation, and the continuing influence of the regional elites of the old regime. Central-local relations are shown to be more orderly in countries with successful financial stabilization. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780309049368
  • Publisher: National Academies Press
  • Publication date: 8/19/1996
  • Series: Laboratory Animal Management: A Series
  • Edition description: New Edition
  • Pages: 180
  • Product dimensions: 9.02 (w) x 6.09 (h) x 0.48 (d)

Table of Contents

1 Laboratory Animals and Public Perspective 1
2 Responsibilities of Animal Care and Use Committees 6
3 Criteria for Selecting Experimental Animals 16
4 Genetic Management of Breeding Colonies 35
5 Husbandry 44
6 Veterinary Care 85
7 Facilities 114
8 Rodents that Require Special Consideration 122
Appendix Sources of Information on Importing Rodents 159
Index 161
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