The Role of Genetics in Breast and Reproductive Cancers / Edition 1

The Role of Genetics in Breast and Reproductive Cancers / Edition 1

by Piri Welcsh
     
 

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.See more details below

Overview

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Product Details

ISBN-13:
9781441904768
Publisher:
Springer New York
Publication date:
09/22/2009
Series:
Cancer Genetics Series
Edition description:
2010
Pages:
344
Product dimensions:
6.30(w) x 9.30(h) x 1.10(d)

Table of Contents

Part I Recognition of Hereditary Breast and Reproductive Cancer Syndromes

1 Cancer Genetics in the Clinic: The Challenges and Responsibilities of Counseling and Treating Women at Risk Robin L. Bennett 3

2 Management of Women with Inherited BRCA1 and BRCA2 Mutations Elizabeth M. Swisher Kristine E. Calhoun 21

Part II Genetic Etiology of Breast and Reproductive Cancers

3 Unclassified Variants in the Breast Cancer Susceptibility Genes BRCA1 and BRCA2 Sean V. Tavtigian 49

4 Recent Advances in Understanding the Cellular Functions of BRCA1 Ellen Solomon Joanna R. Morris 75

5 Recent Advances in Understanding the Cellular Functions of BRCA2 Sylvie Mazoyer 93

6 Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers Georgia Chenevix-Trench Antonis C. Antoniou 107

7 Other Hereditary Breast Cancer Syndromes and Genes Katherine L. Nathanson 131

8 Ovarian and Endometrial Cancer in Patients with Hereditary Non-polyposis Colorectal Cancer Syndrome Kimberly Resnick David Cohn 163

9 Somatic Alterations and Implications in Breast Cancer Carl Ton Jamie Guenthoer Peggy L. Porter 183

10 Somatic Genetic Development in Epithelial Ovarian Cancer Kate Lawrenson Susan J. Ramus Simon A. Gayther 215

Part III Genes and the Environment

11 High-Frequency Low-Penetrance Alleles Paul Pharoah 263

12 Host and Viral Genetics and Risk of Cervical Cancer Janet S. Rader 263

13 Estrogen-Metabolizing Gene Polymorphisms, Genetic Susceptibility, and Pharmacogenomics Johannes C. Huber Eva-Katrin Tempfer-Bentz Johannes Ott Clemens B. Tempfer 285

14 The Future of Discoveries in Breast and Reproductive Cancers: The Genome and Epigenetics Santiago Ropero Manel Esteller315

Index 333

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