The Role of Genetics in Breast and Reproductive Cancers / Edition 1

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This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

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Product Details

  • ISBN-13: 9781441904768
  • Publisher: Springer New York
  • Publication date: 9/22/2009
  • Series: Cancer Genetics Series
  • Edition description: 2010
  • Edition number: 1
  • Pages: 344
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.10 (d)

Meet the Author

Piri L. Welcsh, PhD is a Research Assistant Professor in the Department of Medicine, Division of Medical Genetics at the University of Washington. She received her PhD in Molecular Genetics from The Ohio State University. It was during this time that the seminal paper in which Dr. Mary-Claire King demonstrated that a single gene on chromosome 17, later known as BRCA1, was responsible for many breast and ovarian cancers was published. During Postdoctoral studies at the University of Texas Southwestern Medical Center in Dallas, Dr. Welcsh worked under the guidance of Dr. Anne M. Bowcock and collaborated with Drs. Mary-Claire King and Francis Collins in an attempt to clone BRCA1. Shortly after the gene encoding BRCA1 was identified, Dr. Welcsh joined the research group of Dr. King at the University of Washington where she conducted studies designed to elucidate the biological function of BRCA1. She is currently an independent investigator whose current research goals include the identification and characterization of both genetic and epigenetic mechanisms critical to the development of breast and ovarian cancer.

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Table of Contents

Part I Recognition of Hereditary Breast and Reproductive Cancer Syndromes

1 Cancer Genetics in the Clinic: The Challenges and Responsibilities of Counseling and Treating Women at Risk Robin L. Bennett 3

2 Management of Women with Inherited BRCA1 and BRCA2 Mutations Elizabeth M. Swisher Kristine E. Calhoun 21

Part II Genetic Etiology of Breast and Reproductive Cancers

3 Unclassified Variants in the Breast Cancer Susceptibility Genes BRCA1 and BRCA2 Sean V. Tavtigian 49

4 Recent Advances in Understanding the Cellular Functions of BRCA1 Ellen Solomon Joanna R. Morris 75

5 Recent Advances in Understanding the Cellular Functions of BRCA2 Sylvie Mazoyer 93

6 Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers Georgia Chenevix-Trench Antonis C. Antoniou 107

7 Other Hereditary Breast Cancer Syndromes and Genes Katherine L. Nathanson 131

8 Ovarian and Endometrial Cancer in Patients with Hereditary Non-polyposis Colorectal Cancer Syndrome Kimberly Resnick David Cohn 163

9 Somatic Alterations and Implications in Breast Cancer Carl Ton Jamie Guenthoer Peggy L. Porter 183

10 Somatic Genetic Development in Epithelial Ovarian Cancer Kate Lawrenson Susan J. Ramus Simon A. Gayther 215

Part III Genes and the Environment

11 High-Frequency Low-Penetrance Alleles Paul Pharoah 263

12 Host and Viral Genetics and Risk of Cervical Cancer Janet S. Rader 263

13 Estrogen-Metabolizing Gene Polymorphisms, Genetic Susceptibility, and Pharmacogenomics Johannes C. Huber Eva-Katrin Tempfer-Bentz Johannes Ott Clemens B. Tempfer 285

14 The Future of Discoveries in Breast and Reproductive Cancers: The Genome and Epigenetics Santiago Ropero Manel Esteller315

Index 333

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