Role of the Sarcoplasmic Reticulum in Smooth Muscle No. 246 / Edition 1

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Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertension and pre-term labour. The calcium ion plays a central role in smooth muscle function, increasing in concentration for contraction and decreasing for relaxation. Calcium entry into the cell is facilitated by the sarcoplasmic reticulum (SR).

This book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of the SR and how this may vary among smooth muscle types. Potential therapeutic implications are also discussed.

  • Discusses new and exciting work in this area and identifies promising new research directions.
  • Considers the advances in this relatively unexplored field, offering new insights into the role of the SR muscle.
  • Brings together contributions from key workers, both in basic and clinical science, whose studies range from physiological to pathological and molecular to whole animal.


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Editorial Reviews

Doody's Review Service
Reviewer: Mailen Kootsey, PhD (Loma Linda University)
Description: This book summarizes the papers presented and the discussions at a symposium on smooth muscle held in London at the Novartis Foundation in 2001. The participants and authors are leading researchers in the field, so the book describes the current knowledge about the activation and control of smooth muscle as of that date and the experiments upon which the understanding was based.
Purpose: The purpose of the symposium (and thus of the book) was to review the current thinking about mechanisms of control of smooth muscle contraction, especially the roles of calcium ions and the sarcoplasmic reticulum (SR). Because smooth muscle deficiencies are implicated in numerous health problems (e.g. hypertension), an accurate understanding of these control mechanisms would have widespread implications in healthcare. In his introductory chapter, symposium chair David Eisner suggests eight specific questions for the participants to address, for example: To what extent does the SR contribute to the rise of intracellular calcium ion concentration that activates contraction? Similar questions have been raised for skeletal and cardiac muscle and the control mechanisms in these tissues are better understood. The chapters in this book provide some answers to the eight questions and suggestions for future research.
Audience: The immediate beneficiaries of the symposium were clearly the expert participants who gained insights that could help direct their ongoing research. Nevertheless, this written record will also be helpful to graduate students and researchers moving into the field of smooth muscle. Teachers of graduate or advanced undergraduate courses touching on smooth muscle will also find this book to be a useful reference.
Features: The bulk of this book is made up of papers presented at the symposium. While the material is very technical and specialized, the writing quality is uniformly excellent and the authors include enough illustrations of original data and diagrams of hypotheses to keep the reader's attention. I especially appreciated the detailed transcriptions of the discussions following each paper as well as three general discussion sessions. The reader can thus follow the research community's thinking in drawing conclusions from data and in the planning of new experiments. The book could not end with a complete and accurate description of smooth muscle control, but there is much insight and the working of the scientific process is well illustrated.
Assessment: Complexity is a major theme in biology and medicine and the material in this book illustrates why the theme is appropriate. If there is a single conclusion of this book, it would be that numerous factors and mechanisms interact to determine the contractile response of smooth muscle to varying conditions in the body. The material discussed is highly technical, but the subject is absolutely essential for the physiologist, the basic medical scientist, and ultimately the physician. As a snapshot of understanding at a specific time, the life of the book as state-of-the-art will be limited. But, it is also an excellent illustration of the scientific process and the needed interaction between researchers employing different experimental techniques and contributing from different viewpoints.
From The Critics
Papers from a fall 2001 symposium explore the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function, examining the relationship between calcium release and inhibition and/or promotion of contraction, the control and modulation of the SR in smooth muscle, the extent to which the SR may vary between smooth muscles, and potential therapeutic implications of research. Specific topics include the relationship between the sarcoplasmic reticulum and the plasma membrane, molecular candidates for capacitative and non- capacitative Ca2+ entry in smooth muscle, calcium release by ryanodine receptors in smooth muscle, calcium waves and myometrial signalling, and the physiological significance of smooth muscle Ca2+ stores. Annotation c. Book News, Inc., Portland, OR

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780470844793
  • Publisher: Wiley
  • Publication date: 7/25/2002
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 296
  • Product dimensions: 6.18 (w) x 9.23 (h) x 0.74 (d)

Table of Contents

Chair's introduction (David Eisner).

Role of the sarcoplasmic reticulum in uterine smooth muscle (Susan Wray, Sajeera Kupittayanant and Tony Shmigol).

Relationship between the sarcoplasmic reticulum and the plasma membrane (Cheng-Han Lee, Damon Poburko, Kuo-Hsing Kuo, Chun Seow and Cornelis van Breemen).

General discussion I The role of calmodulin in smooth muscle contraction.

Ca-2+ signalling and Ca-2+-activated K?+ channels in smooth muscle (John G. McCarron, Karen N. Bradley and Thomas C. Muir).

Additional fluxes of activator Ca-2+ accompanying Ca-2+ release from the sarcoplasmic reticulum triggered by InsP3-mobilizing agonists (Luc Raeymaekers, Bernd Nilius, Thomas Voets, Ludwig Missiaen, Kurt Van Baelen, Jo Vanoevelen and Frank Wuytack).

Molecular candidates for capacitative and non-capacitative Ca-2+ entry in smooth muscle (Ryuji Inoue and Yasuo Mori).

Regulation of Ca-2+ entry pathways by both limbs of the phosphoinositide pathway (Colin W. Taylor).

Calcium release by ryanodine receptors in smooth muscle (M. I. Kotlikoff, Yong-Xiao Wang, Hong-Bo Xin and Guanju Ji).

Organization of Ca-2+ stores in vascular smooth muscle: functional implications (Mordecai P. Blaustein, Vera A. Golovina, Hong Song, Jacqueline Choate, Lubomira Lencesova, Shawn W. Robinson, and W. Gil Wier).

Molecular basis and physiological functions of dynamic Ca-2+ signalling in smooth muscle cells (Masamitsu Iino).

Calcium release events in excitation-contraction coupling in smooth muscle (T. B. Bolton, D. V. Gordienko, V. Pucovsk?, S. Parsons and O. Povstyan).

Sarcoplasmic reticulum, calcium waves and myometrial signalling (Roger C. Young).

Sarcoplasmic reticulum and membrane currents (Gerald M. Herrera and Mark T. Nelson).

Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles (Theodor Burdyga and Susan Wray).

General discussion II The physiological significance of smooth muscle Ca-2+ stores.

The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice (R. J. Paul, G. E. Shull and E. G. Kranias).

The sarcoplasmic reticulum in disease and smooth muscle dysfunction: therapeutic potential (A. F. Brading).

The sarcoplasmic reticulum: then and now (Andrew P. Somlyo and Avril V. Somlyo).

Final General Discussion.

Index of Contributors.

Subject Index.

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