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Current topics are included, from immunotoxicology, to nonrodent experiment design, to the future of In Vitro techniques. Avoiding dry mathematical and theoretical discussion in favor of practical guidance, this is the best reference available for understanding and performing safety assessments.
Information Sources: Building and Maintaining Data Files (D. Larson, et al.).
Screens in Safety and Hazard Assessments (S. Gad).
Acute Toxicity Testing in Drug Safety Evaluation (C. Chengelis).
Subchronic and Chronic Toxicity Studies (S. Gad).
Developmental and Reporductive Toxicity Testing (R. Clark).
Carcinogenicity Studies (L. DePass).
Safety Assessment of Inhalant Drugs (B. Leong).
Irritation and Local Tissue Tolerance in Pharmaceutical Safety Assessment (S. Gad).
Routes, Formulations, and Dose Designs (S. Gad).
Occupational Toxicology in the Pharmaceutical Industry (D. G?ler).
Immunotoxicology in Pharmaceutical Development (P. Guzzie).
Special Case: Nonrodent Studies (G. Haggerty).
The Application of In Vitro Techniques in Drug Safety Assessment (P. Williams, et al.).