Table of Contents
Contents
Preface vii
Contributors ix
Acknowledgments xv
SECTION 1: Epidemiology and biology of HIV infection
1 The global epidemiology of HIV/AIDS 3
Irum Zaidi, Kevin M De Cock
2 The origins and diversification of HIV 15
Michael Worobey, Guan-Zhu Han
3 Molecular biology of HIV: implications for new therapies 25
Warner C Greene, B Matija Peterlin, Matthew H Stremlau
4 The immune response to HIV 45
Clive M Gray, Pamela Gumbi, Lycias Zembe, Mopo Radebe, Bruce Walker
5 Viral and host determinants of HIV-1 disease progression 59
Danie¨lle van Manen, Ange´lique B van ’t Wout, Hanneke Schuitemaker
6 Acute HIV infection 77
Anthony D Kelleher, David A Cooper
7 Biology of HIV-1 transmission 89
Julie Overbaugh
SECTION 2: Prevention, diagnosis, and treatment of HIV infection
8 The design of a global HIV vaccine 97
Jerome H Kim, Nelson L Michael
9 HIV prevention 113
Salim S Abdool Karim
10 Laboratory testing for HIV infection 123
James C Shepherd, Oliver Laeyendecker, Thomas C Quinn
11 Overview of antiretroviral therapy 133
Susa Coffey, Paul A Volberding
12 Development and transmission of HIV drug resistance 155
Mark A Wainberg, Gerasimos J Zaharatos
13 Pharmacology of antiretroviral drugs 169
Concepta Merry, Charles W Flexner
14 Complications resulting from antiretroviral therapy for HIV infection 177
David Nolan, Simon Mallal, Peter Reiss
SECTION 3: Diseases associated with HIV infection
15 Oral complications of HIV infection 195
John S Greenspan, Deborah Greenspan
16 Ocular manifestations of AIDS 207
James P Dunn
17 Global HIV and dermatology 219
Toby Maurer, Robert Michelleti
18 Gastrointestinal disorders in HIV including diarrhea 237
Marie-Louise C Vachon, Douglas T Dieterich
19 Primary neurological manifestation of HIV/AIDS 249
David B Clifford, Mengesha A Teshome
20 Psychiatric barriers and the international AIDS epidemic 257
Chiadi U Onyike, Andrew F Angelino,
Glenn J Treisman
21 Cardiovascular complications of HIV infection 267
Rakesh K Mishra
22 Endocrine complications of HIV infection 275
Steven A Taylor, Carl Grunfeld,
Morris Schambelan
23 Renal complications of HIV infection 287
Jula K Inrig, Lynda A Szczech,
Trevor E Gerntholtz, Paul E Klotman
24 Pneumocystis pneumonia 297
Robert J Blount, J Lucian Davis,
Laurence Huang
25 Other HIV-related pneumonias 313
John G Bartlett
26 HIV-associated tuberculosis 325
Leyla Azis, Edward C Jones-Lo´pez,
Jerrold J Ellner
27 Disseminated Mycobacterium avium complex and other atypical mycobacterial infections 349
Mark A Jacobson
28 Candida in HIV infection 359
William G Powderly
29 Cryptococcosis and other fungal infections
(histoplasmosis and coccidioidomycosis)
in HIV-infected patients 369
Kathleen R Page, Richard E Chaisson,
Merle Sande
30 Infection due to Penicillium marneffei 389
Thira Sirisanthana, Khuanchai Supparatpinyo
31 AIDS-associated toxoplasmosis 397
Pablo A Moncada, Jose G Montoya
32 Hepatitis virus infections 411
Marion G Peters, Monika Sarkar
33 Bartonella infections in HIV-infected individuals 421
Jane E Koehler
34 Management of herpesvirus infections
(cytomegalovirus, herpes simplex virus, and varicella-zoster virus) 433
W Lawrence Drew, Kim S Erlich
35 HIV-associated malignancies 455
Ronald T Mitsuyasu
36 STDs and syphilis 467
Elysia Larson, Jeffrey D Klausner
SECTION 4: Prevention and management
37 Prevention of mother-to-child transmission of HIV-1 485
Lynne M Mofenson
38 Managing HIV infection in children and adolescents 509
Elizabeth H Doby, Andrew T Pavia
39 Special issues regarding women with HIV infection 521
Ruth M Greenblatt, Monica Gandhi
40 HIV disease among substance users:
treatment issues 537
R Douglas Bruce, Frederick L Altice,
Gerald Friedland
41 The HIV-infected international traveler 551
Malcolm John
Index 561
