Schizophrenia Genesis: The Origins of Madness

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Sorting out fact from fiction, one of the world's leading experts presents an absorbing account of what is actually know about the complex subject of schizophrenia.

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Editorial Reviews

Gottesman psychology and pediatrics, U. of Virginia draws on the latest family, twin, and adoption research, as well as on environmental studies and recent findings in neurobiology, to investigate the origins of schizophrenia. His discussion of the latest thinking on gene-environment interaction assumes no prior knowledge of genetics or molecular biology. He also includes numerous autobiographical accounts by schizophrenics and their relatives, providing a personal glimpse from those experiencing this disorder. Annotation c. Book News, Inc., Portland, OR
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Product Details

  • ISBN-13: 9780716721475
  • Publisher: Holt, Henry & Company, Inc.
  • Publication date: 9/28/1990
  • Series: Series of Books in Psychology
  • Edition description: REV
  • Pages: 316
  • Sales rank: 983,629
  • Product dimensions: 6.12 (w) x 9.22 (h) x 0.63 (d)

Table of Contents

Preface xi
1 In the Beginning 1
Early Accounts of Schizophrenia 5
Historical Views of Insanity and Its Treatment: Some Misguided Clues to Causes 9
Origins of Modern Considerations in Mental Disorders 12
2 How Do We Know When It's Schizophrenia? 17
Reducing Uncertainty in Diagnosing Schizophrenia 19
Genuine Schizophrenia: A Case History 24
Schizophrenia's Forgeries and False Leads 28
Experiments in Making Clinical Judgments 30
A Prototype for Diagnosing Schizophrenia 33
Diagnosing Schizophrenia: An Integrated Summary 36
Schizophrenia and Childhood Psychoses 37
3 Anguished Voices I: Personal Accounts of Survivors 40
Where Did I Go? 41
The Messiah Quest 44
After the Funny Farm 50
The Hard Road Back 54
Reprise 59
4 Schizophrenia across Time and Space 60
Lessons from Epidemiology 61
Is Schizophrenia a Recent Disease? 63
From Raw Data toward Strategic Information 64
The Age of Onset of Schizophrenia 68
The Demographics of Longevity 70
Attempts to Discover the True Number of Schizophrenics 72
From Mental Hospital Statistics to Community Estimates 73
The Distribution of Schizophrenia by Social Class 76
Schizophrenia around the World 79
Reprise 81
5 Is Schizophrenia Inherited Genetically? 82
A Genetics Primer 84
From Simple to Complex Schemes of Inheritance 86
Foundations for a Genetic Position 93
Family Studies 94
Summary 102
6 The Evidence from Twin Studies 104
Classical Twin Studies: 1928-1953 105
Contemporary Twin Studies 109
Challenges to Received Wisdom 114
Severity as an Indicator of Genetic Loading 116
Reprise: Old and New Twin Studies 116
Understanding Discordance in Identical Twins 117
Revitalizing Research on Discordant Twin Pairs 119
Identical Twins Reared Apart 120
The Offspring of Schizophrenic Twins 123
Identical Quadruplets Concordant for Schizophrenia 125
Conclusion 126
Three Generations of Schizophrenia 127
7 Is Schizophrenia Contagious Psychologically? 133
Adoption Strategies 134
Heston's Adoption Study in Oregon 136
The Evidence from Denmark 138
A Meta-Analysis of Offspring Risk 140
Who Raised Schizophrenic Adoptees? The Kety Strategy 142
Wender's Cross-Fostering Research 146
Adoption Strategies in Finland 147
Overview of Adoption Results 148
8 The Role of Psychosocial and Environmental Stressors 150
Acute and Persistent Life Events 152
The "New Look" in Family Influences 155
Obstetrical Complications and Other Somatic Risks 160
Seek Simplicity and Distrust It 162
Summary 163
9 Anguished Voices II: Personal Accounts of Family Members 166
Making the Best of It 167
A Father's Thoughts 170
Confessions of a Schizophrenic's Daughter 177
10 Schizophrenia, Society, and Social Policy 184
Patterns of Death and Physical Illness 185
Criminality and Violence 190
Sexuality, Marriage, Fertility, and Divorce 193
Genetic Counseling 197
Legal Constraints: Marriage, Immigration, and Sterilization 204
The Nazi "Solution" 207
A Parent's View on Enforcing Medication 210
11 The Big Picture 214
Models as Maps: Where Are We and Where Do We Need to Go? 216
Models for the Development of Schizophrenia: The Pathway from Genotype to Psychopathology 218
Gene-Environment Models for the Transmission of Schizophrenia 227
Summary 232
Conclusions 233
12 What Next? The Decade of the Brain 234
Neurobiology and Schizophrenia 236
The Continuing Promise of Longitudinal High-Risk Studies 239
Genetic Markers and Genetic Linkage 242
Conclusions 246
A Story to End the Story 247
Giving Love ... and Schizophrenia 247
References and Bibliography 256
Name Index 285
Subject Index 293
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