Science of the Placebo: Toward an Interdisciplinanary Research Agenda / Edition 1

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Based on a meeting in November 2000, this book brings together researchers from a wide range of disciplines to examine the biological, behavioral, social, cultural and ethical aspects related to the placebo effect. Perspectives on the necessity for including a placebo in randomized clinical trials will also be examined.
This is the first attempt to examine the evidence-base of the placebo effect and will provide important information for clinicans.

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Product Details

  • ISBN-13: 9780727915948
  • Publisher: Wiley
  • Publication date: 3/25/2002
  • Series: Evidence-Based Medicine Workbks. Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 346
  • Product dimensions: 6.15 (w) x 9.25 (h) x 0.80 (d)

Table of Contents



1 An Overview.

Section 1: Historical and Ethical Perspectives.

2 “Seeing” the Placebo Effect: Historical Legacies and Present Opportunities.

3 Ethical Issues in Use of Placebo in Medical Practice and Clinical Trials.

Section 2: Elucidating Placebo Effects: Explanatory Mechanisms.

4 Explanatory Mechanisms for Placebo Effects: Cultural Influences and the Meaning Response.

5 Explanatory Mechanisms for Placebo Effects: Cognition, Personality and Social Learning.

6 Explanatory Mechanisms for Placebo Effects: Pavlovian Conditioning.

7 Regression to the Mean or Placebo Effect?.

Section 3: Elucidating Placebo Effects: Intervening Psychophysiology.

8 Neuriendocrine Meidators of Placebo Effects on Immunity.

9 Endogenous Opioid and Non-Opioid Pathways as Mediators of Placebno Analgesia.

Section 4: Use of Placebo Groups in Clinical Trials-Methodological and Ethical Issues.

10 Placebo controlled Trials and Active Controlled Trials: Ethics and Inference.

11 When is it Appropriate to Use a Placebo Arm in a Trial?.

12 The Pros and Cons of Non-Inferiority (Equivalence) Trials.

13 Use of Placebo in Large-Scale, Pragmatic Trials.

14 Placebo Controls in Clinical Trials of New Therapies for Conditions for which there are Known Effective Treatments.

Section 5: Priorities for Future Research.

15 The Research and Ethical Agenda.

Section 6: Conclusions and Future Directions.

16 Conclusions and Future Directions.



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