The Search for New Anticancer Drugs

Overview

Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science.
This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then...
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Paperback (Softcover reprint of the original 1st ed. 1992)
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Overview

Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science.
This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.
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Editorial Reviews

From the Publisher
' Overall, then, a well-edited and pretty up-to-date collection of interesting and useful articles. I would recommend it for a post-graduate seminar or debate on the medicinal chemistry of cancer. '
Annals of Oncology

' This book is recommended both for scientists engaged in anticancer drug development and for the interested outsider. In general it is well produced and, apart from a few exceptions, most of the chemical structures are refreshingly well drawn. The individual chapters are nicely sub-sectioned and all are comprehensively referenced to the primary literature; indeed some of the references have already been useful in our own work. '
Clinical Oncology, 5:4

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Product Details

  • ISBN-13: 9789401066594
  • Publisher: Springer Netherlands
  • Publication date: 12/31/2013
  • Series: Cancer Biology and Medicine Series , #3
  • Edition description: Softcover reprint of the original 1st ed. 1992
  • Pages: 296
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.62 (d)

Table of Contents

1. Is there a future for the small molecule in developmental cancer chemotherapy?.- 2. The role of medicinal chemistry in the discovery of DNA-active anticancer drugs: from random searching, through lead development, to de novo design.- 3. In vitro systems for anticancer drug testing.- 4. Tumour hypoxia: challenges for cancer chemotherapy.- 5. Computer modelling and drug design.- 6. Differentiation inducers and their potential use in the treatment of acute myelogenous leukaemia.- 7. Angiosuppression.- 8. Preclinical evaluation and phase I trials.- 9. Evaluation: how should a new treatment be evaluated?.- 10. Oncogene-targeted antisense oligonucleotides: tools for genetic analysis or new anticancer drugs?.
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