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Doody's Review ServiceReviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: This useful book covers several major areas of modern research, development, practical applications of molecular science, and different modes of molecular discovery, emphasizing the historical and ongoing importance of empirical strategies.
Purpose: The aim is to make the case that finding useful molecules is far from simple and that empirical strategies will complement and even outperform rational approaches in many areas for the foreseeable future. The essential aim is to compare different modes of molecular discovery, with an emphasis on the historical and ongoing importance of empirical strategies.
Audience: The author intends this book for scientists, professionals, and students interested in the general aspects of molecular discovery, as well as the thought processes behind experimental approaches.
Features: The book begins with a very informative introduction to molecules. The 10 chapters deal with the differing modes of molecular discovery; biological precedents for evolutionary approaches; enzyme evolution and design; functional nucleic acid discovery; antibodies and other recognition molecules; general aspects of molecular recognition; small molecule discovery approaches; rational molecular design; the interplay between empirical and rational strategies; and their ongoing roles in the future of molecular discovery. The book is beautifully illustrated.
Assessment: This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful.