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Doody's Review ServiceReviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This monograph originated in a symposium held on sepsis by the Novartis Foundation in London in February 2006.
Purpose: Summary papers are provided with edited and referenced discussion from symposium participants.
Audience: With contributions from world thought leaders in sepsis, this is an appropriate contribution for basic researchers and academic intensivists facing sepsis.
Features: Laboratory work with cellular and molecular biology is the focus of the presentations, with mechanisms and utility of controlled apoptosis, manipulation of signal transduction, optimal resuscitation additives, and neuroendocrine response to sepsis receiving particular emphasis. Chapters are well written reviews of the topics and include discussion sections. Each chapter contains a short reference list focused on the best papers from primary literature dating to within a year of symposium activity. Line drawings and tables are occasionally used. The table of contents lists chapters and authorship while both a contributor index and a subject index optimize access to content.
Assessment: The book retains the effective conversational style of the symposium on which it is based. Because of careful editing and reference citation, readers can easily follow the contributions of various participants. This is a worthwhile update of many of the themes raised in academic discussion on sepsis management.