Sepsis: New Insights, New Therapies, Novartis Foundation Symposium / Edition 1

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Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics, and metabolism.

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Editorial Reviews

Doody's Review Service
Reviewer: David J. Dries, MD (University of Minnesota Medical School)
Description: This monograph originated in a symposium held on sepsis by the Novartis Foundation in London in February 2006.
Purpose: Summary papers are provided with edited and referenced discussion from symposium participants.
Audience: With contributions from world thought leaders in sepsis, this is an appropriate contribution for basic researchers and academic intensivists facing sepsis.
Features: Laboratory work with cellular and molecular biology is the focus of the presentations, with mechanisms and utility of controlled apoptosis, manipulation of signal transduction, optimal resuscitation additives, and neuroendocrine response to sepsis receiving particular emphasis. Chapters are well written reviews of the topics and include discussion sections. Each chapter contains a short reference list focused on the best papers from primary literature dating to within a year of symposium activity. Line drawings and tables are occasionally used. The table of contents lists chapters and authorship while both a contributor index and a subject index optimize access to content.
Assessment: The book retains the effective conversational style of the symposium on which it is based. Because of careful editing and reference citation, readers can easily follow the contributions of various participants. This is a worthwhile update of many of the themes raised in academic discussion on sepsis management.
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Product Details

  • ISBN-13: 9780470027981
  • Publisher: Wiley
  • Publication date: 4/9/2007
  • Series: Novartis Foundation Symposia Series , #194
  • Edition number: 1
  • Pages: 302
  • Product dimensions: 6.36 (w) x 9.31 (h) x 0.79 (d)

Meet the Author

The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledgeof science and in particular encourages international co-operationin scientific research.
Chairman: Mitchell Fink

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Table of Contents

Symposim on Sepsis: new insights, new therapies, held at theNovartis Foundation, London, 14-16 February 2006.

Editors: Derek J. Cahdwick (Organizer) and Jamie Goode.

This Symposim was based on a proposal made by Mitchell Fink andMervyn Singer.

Chair’s introduction (Mitchell P. Fink).


Strategies to modulate cellular energetic metabolism duringsepsis (Alessandro Protti and MervynSinger).


Immunostimulation is a rational therapeutic strategy in sepsis(Jérôme Pugin).


Blockade of apoptosis as a rational therapeutic strategy for thetreatment of sepsis (Alfred Ayala, Doreen E. Wesche-Soldato,Mario Perl, Joanne L. Lomas-Neira, Ryan Swan andChun-Shiang Chung).


Modulating neutrophil apoptosis (John C. Marshall, ZeenatMalam and Songhui Jia).


HMGB1 as a potential therapeutic target(Haichao Wang, WeiLi, Richard Goldstein, Kevin J. Traceyand Andrew E.Sama).


Poly (ADP-ribose) polymerase activation and circulatory shock(Csaba Szabó).


Choosing the right substrate (Xavier Leverve, CécileBatandier and Eric Fontaine).


Inhibiting glycogen synthase kinase 3β in sepsis(Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A.Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, SimonJ. Foster, Muhammad M. Yaqoob and ChristophThiemermann).


Ethyl pyruvate: a novel treatment for sepsis (Mitchell P.Fink).


General discussion I.

Cytoprotective and anti-inflammatory actions of carbon monoxidein organ injury and sepsis models(Stefan W. Ryter andAugustine M. K. Choi).


The hypothalamic pituitary adrenal axis in sepsis (AndreaPolito, Jérôme Aboab andDjillaliAnnane).


Modulating the endocrine response in sepsis: insulin and bloodglucose control (Ilse Vanhorebeek, Lies Langoucheand Greet Van den Berghe).


The neuronal strategy for inflammation(LuisUlloaand Ping Wang).


Beta-blockade in burns (C. T. Pereira, M. G.Jeschke and D. N. Herndon).


System interactions (Mervyn Singer).


Protecting the permeability pore and mitochondrial biogenesis(C. A. Piantadosi, M. S. Carraway, D. W. Haden andH. B. Suliman).


Contributor Index.

Subject index.

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