Sequence -- Evolution -- Function: Computational Approaches in Comparative Genomics / Edition 1

Sequence -- Evolution -- Function: Computational Approaches in Comparative Genomics / Edition 1

by Eugene Koonin, Michael Y. Galperin
     
 

ISBN-10: 1402072740

ISBN-13: 9781402072741

Pub. Date: 11/30/2002

Publisher: Springer US

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches

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Overview

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis.

Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

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Product Details

ISBN-13:
9781402072741
Publisher:
Springer US
Publication date:
11/30/2002
Edition description:
2003
Pages:
462
Product dimensions:
6.36(w) x 9.50(h) x 1.22(d)

Table of Contents

Preface
Introduction: Personal Interludes1
Ch. 1Genomes from Phage to Human3
Ch. 2The Evolutionary Concept in Genetics and Genomics25
Ch. 3Information Sources for Genomics51
Ch. 4Principles and Methods of Sequence Analysis111
Ch. 5Genome Annotation and Analysis193
Ch. 6Comparative Genomics and New Evolutionary Biology227
Ch. 7Evolution of Central Metabolic Pathways: The Playground of Non-orthologous Gene Displacement295
Ch. 8Genomes and the Protein Universe357
Ch. 9Epilogue: Peering through the crystal ball371
Appendices381
References403
Index457

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