The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics / Edition 1

The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics / Edition 1

by Bryan L. Roth
     
 

ISBN-10: 1588295680

ISBN-13: 9781588295682

Pub. Date: 06/28/2006

Publisher: Springer-Verlag New York, LLC

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in

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Overview

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Product Details

ISBN-13:
9781588295682
Publisher:
Springer-Verlag New York, LLC
Publication date:
06/28/2006
Series:
Receptors Series
Edition description:
2006
Pages:
618
Product dimensions:
6.20(w) x 9.30(h) x 1.30(d)

Table of Contents

1Molecular biology and genomic organization of G protein-coupled serotonin receptors1
2Structure and function reveal insights in the pharmacology of 5-HT receptor subtypes39
3Polymorphic and posttranscriptional modifications of 5-HT receptor structure : functional and pathological implications59
4Strategies for the development of selective serotonergic agents91
55-HT receptor signal transduction pathways143
6Agonist-directed trafficking of 5-HT receptor-mediated signal transduction207
7Identification of 5-HT[subscript 2] and 5-HT[subscript 4] receptor-interacting proteins : a proteomic approach237
85-HT receptor-associated proteins (FRAPs) : relevance for targeting, trafficking, and signal transduction257
9Cellular and subcellular localization of serotonin receptors in the central nervous system277
10Chemical neuroanatomy of 5-HT receptor subtypes in the mammalian brain319
11Modulation of the neuronal activity and neurotransmitter release by 5-HT[subscript 1A] and 5-HT[subscript 1B/1D] receptors365
12Electrophysiology of 5-HT[subscript 2A] receptors and relevance for hallucinogen and atypical antipsychotic drug actions403
13The emergence of 5-HT[subscript 2B] receptors as targets to avoid in designing and refining pharmaceuticals419
14The 5-HT[subscript 3] receptor439
155-HT[subscript 3] and 5-HT[subscript 4] receptors as targets for drug discovery for dementia459
16Electrophysiological properties of G[alpha][subscript s]-coupled 5-HT receptors (5-HT[subscript 4], 5-HT[subscript 6], 5-HT[subscript 7])481
175-HT[subscript 6] receptors as targets for the treatment of cognitive deficits in schizophrenia495
185-HT[subscript 7] receptors as favorable pharmacological targets for drug discovery517
19Serotonin system gene knockouts : a story of mice with implications for man537
20Effects of serotonin-related gene deletion on measures of anxiety, depression, and neurotransmission577

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